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Sex differences in long-term outcomes in older adults undergoing invasive treatment for non-ST elevation acute coronary syndrome: An ICON-1 sub-study
BACKGROUND: Cardiovascular disease is the leading cause of mortality for females globally, yet females are underrepresented in studies of acute coronary syndrome (ACS). Studies investigating sex-related differences in clinical outcomes of patients with non-ST elevation ACS (NSTEACS) have reported di...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9465323/ https://www.ncbi.nlm.nih.gov/pubmed/36105237 http://dx.doi.org/10.1016/j.ijcha.2022.101118 |
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author | Ratcovich, Hanna Alkhalil, Mohammad Beska, Benjamin Holmvang, Lene Lawless, Mike Gede Dennis Sukadana, I. Wilkinson, Chris Kunadian, Vijay |
author_facet | Ratcovich, Hanna Alkhalil, Mohammad Beska, Benjamin Holmvang, Lene Lawless, Mike Gede Dennis Sukadana, I. Wilkinson, Chris Kunadian, Vijay |
author_sort | Ratcovich, Hanna |
collection | PubMed |
description | BACKGROUND: Cardiovascular disease is the leading cause of mortality for females globally, yet females are underrepresented in studies of acute coronary syndrome (ACS). Studies investigating sex-related differences in clinical outcomes of patients with non-ST elevation ACS (NSTEACS) have reported divergent results, and it is unknown whether long-term outcomes for older people with NSTEACS differ between males and females. METHODS: The multi-centre prospective cohort study, ICON-1, consisted of patients aged ≥75 years undergoing coronary angiography following NSTEACS. The primary composite endpoint was all-cause mortality, myocardial infarction, unplanned revascularisation, stroke, and bleeding. We report outcomes at five-years by sex. RESULTS: Of 264 patients, 102 (38.6%) females and 162 (61.4%) males completed the five-year follow-up and were included in the analytic cohort. At admission, females were older than males (82 ± 4.3 years vs 80.0 ± 4.1 years p = 0.018). Co-morbidity profile and GRACE score were similar between the groups. There were no differences in the provision of invasive or pharmacological treatments between sexes. At five-years, there were no association between sex and the primary outcome. CONCLUSION: In older adults with invasive treatment of NSTEACS, provision of guideline-indicated care and long-term clinical outcomes were similar between males and females. |
format | Online Article Text |
id | pubmed-9465323 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-94653232022-09-13 Sex differences in long-term outcomes in older adults undergoing invasive treatment for non-ST elevation acute coronary syndrome: An ICON-1 sub-study Ratcovich, Hanna Alkhalil, Mohammad Beska, Benjamin Holmvang, Lene Lawless, Mike Gede Dennis Sukadana, I. Wilkinson, Chris Kunadian, Vijay Int J Cardiol Heart Vasc Original Paper BACKGROUND: Cardiovascular disease is the leading cause of mortality for females globally, yet females are underrepresented in studies of acute coronary syndrome (ACS). Studies investigating sex-related differences in clinical outcomes of patients with non-ST elevation ACS (NSTEACS) have reported divergent results, and it is unknown whether long-term outcomes for older people with NSTEACS differ between males and females. METHODS: The multi-centre prospective cohort study, ICON-1, consisted of patients aged ≥75 years undergoing coronary angiography following NSTEACS. The primary composite endpoint was all-cause mortality, myocardial infarction, unplanned revascularisation, stroke, and bleeding. We report outcomes at five-years by sex. RESULTS: Of 264 patients, 102 (38.6%) females and 162 (61.4%) males completed the five-year follow-up and were included in the analytic cohort. At admission, females were older than males (82 ± 4.3 years vs 80.0 ± 4.1 years p = 0.018). Co-morbidity profile and GRACE score were similar between the groups. There were no differences in the provision of invasive or pharmacological treatments between sexes. At five-years, there were no association between sex and the primary outcome. CONCLUSION: In older adults with invasive treatment of NSTEACS, provision of guideline-indicated care and long-term clinical outcomes were similar between males and females. Elsevier 2022-09-06 /pmc/articles/PMC9465323/ /pubmed/36105237 http://dx.doi.org/10.1016/j.ijcha.2022.101118 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Paper Ratcovich, Hanna Alkhalil, Mohammad Beska, Benjamin Holmvang, Lene Lawless, Mike Gede Dennis Sukadana, I. Wilkinson, Chris Kunadian, Vijay Sex differences in long-term outcomes in older adults undergoing invasive treatment for non-ST elevation acute coronary syndrome: An ICON-1 sub-study |
title | Sex differences in long-term outcomes in older adults undergoing invasive treatment for non-ST elevation acute coronary syndrome: An ICON-1 sub-study |
title_full | Sex differences in long-term outcomes in older adults undergoing invasive treatment for non-ST elevation acute coronary syndrome: An ICON-1 sub-study |
title_fullStr | Sex differences in long-term outcomes in older adults undergoing invasive treatment for non-ST elevation acute coronary syndrome: An ICON-1 sub-study |
title_full_unstemmed | Sex differences in long-term outcomes in older adults undergoing invasive treatment for non-ST elevation acute coronary syndrome: An ICON-1 sub-study |
title_short | Sex differences in long-term outcomes in older adults undergoing invasive treatment for non-ST elevation acute coronary syndrome: An ICON-1 sub-study |
title_sort | sex differences in long-term outcomes in older adults undergoing invasive treatment for non-st elevation acute coronary syndrome: an icon-1 sub-study |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9465323/ https://www.ncbi.nlm.nih.gov/pubmed/36105237 http://dx.doi.org/10.1016/j.ijcha.2022.101118 |
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