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Advances in the study of HLA class Ib in maternal-fetal immune tolerance
The HLA class Ib molecule is an alloantigen that causes transplant rejection on behalf of individual human and plays an important role in maternal-fetal immune tolerance. Early studies on HLA class Ib focused on the mechanism of HLA-G-induced immune escape, but in recent years, studies on the mechan...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9465335/ https://www.ncbi.nlm.nih.gov/pubmed/36105800 http://dx.doi.org/10.3389/fimmu.2022.976289 |
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author | Yang, Yiran Wang, Wanning Weng, Jing Li, Huifang Ma, Yanmin Liu, Lingyan Ma, Wei |
author_facet | Yang, Yiran Wang, Wanning Weng, Jing Li, Huifang Ma, Yanmin Liu, Lingyan Ma, Wei |
author_sort | Yang, Yiran |
collection | PubMed |
description | The HLA class Ib molecule is an alloantigen that causes transplant rejection on behalf of individual human and plays an important role in maternal-fetal immune tolerance. Early studies on HLA class Ib focused on the mechanism of HLA-G-induced immune escape, but in recent years, studies on the mechanism of HLA-G have deepened and gradually explored the mechanism of HLA-E and HLA-F, which are also HLA class Ib molecules. In the maternal-fetal interface, trophoblast cells express HLA class Ib molecules to protect the fetus from maternal immune cells by binding to inhibitory receptors of decidual immune cells (DICs) and shifting Th1/Th2 balance toward Th2 bias. Further studies on the molecular mechanism of HLA class Ib molecules provide a reference for its application in the field of clinical assisted reproduction. |
format | Online Article Text |
id | pubmed-9465335 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94653352022-09-13 Advances in the study of HLA class Ib in maternal-fetal immune tolerance Yang, Yiran Wang, Wanning Weng, Jing Li, Huifang Ma, Yanmin Liu, Lingyan Ma, Wei Front Immunol Immunology The HLA class Ib molecule is an alloantigen that causes transplant rejection on behalf of individual human and plays an important role in maternal-fetal immune tolerance. Early studies on HLA class Ib focused on the mechanism of HLA-G-induced immune escape, but in recent years, studies on the mechanism of HLA-G have deepened and gradually explored the mechanism of HLA-E and HLA-F, which are also HLA class Ib molecules. In the maternal-fetal interface, trophoblast cells express HLA class Ib molecules to protect the fetus from maternal immune cells by binding to inhibitory receptors of decidual immune cells (DICs) and shifting Th1/Th2 balance toward Th2 bias. Further studies on the molecular mechanism of HLA class Ib molecules provide a reference for its application in the field of clinical assisted reproduction. Frontiers Media S.A. 2022-08-29 /pmc/articles/PMC9465335/ /pubmed/36105800 http://dx.doi.org/10.3389/fimmu.2022.976289 Text en Copyright © 2022 Yang, Wang, Weng, Li, Ma, Liu and Ma https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Yang, Yiran Wang, Wanning Weng, Jing Li, Huifang Ma, Yanmin Liu, Lingyan Ma, Wei Advances in the study of HLA class Ib in maternal-fetal immune tolerance |
title | Advances in the study of HLA class Ib in maternal-fetal immune tolerance |
title_full | Advances in the study of HLA class Ib in maternal-fetal immune tolerance |
title_fullStr | Advances in the study of HLA class Ib in maternal-fetal immune tolerance |
title_full_unstemmed | Advances in the study of HLA class Ib in maternal-fetal immune tolerance |
title_short | Advances in the study of HLA class Ib in maternal-fetal immune tolerance |
title_sort | advances in the study of hla class ib in maternal-fetal immune tolerance |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9465335/ https://www.ncbi.nlm.nih.gov/pubmed/36105800 http://dx.doi.org/10.3389/fimmu.2022.976289 |
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