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Advances in the study of HLA class Ib in maternal-fetal immune tolerance

The HLA class Ib molecule is an alloantigen that causes transplant rejection on behalf of individual human and plays an important role in maternal-fetal immune tolerance. Early studies on HLA class Ib focused on the mechanism of HLA-G-induced immune escape, but in recent years, studies on the mechan...

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Autores principales: Yang, Yiran, Wang, Wanning, Weng, Jing, Li, Huifang, Ma, Yanmin, Liu, Lingyan, Ma, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9465335/
https://www.ncbi.nlm.nih.gov/pubmed/36105800
http://dx.doi.org/10.3389/fimmu.2022.976289
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author Yang, Yiran
Wang, Wanning
Weng, Jing
Li, Huifang
Ma, Yanmin
Liu, Lingyan
Ma, Wei
author_facet Yang, Yiran
Wang, Wanning
Weng, Jing
Li, Huifang
Ma, Yanmin
Liu, Lingyan
Ma, Wei
author_sort Yang, Yiran
collection PubMed
description The HLA class Ib molecule is an alloantigen that causes transplant rejection on behalf of individual human and plays an important role in maternal-fetal immune tolerance. Early studies on HLA class Ib focused on the mechanism of HLA-G-induced immune escape, but in recent years, studies on the mechanism of HLA-G have deepened and gradually explored the mechanism of HLA-E and HLA-F, which are also HLA class Ib molecules. In the maternal-fetal interface, trophoblast cells express HLA class Ib molecules to protect the fetus from maternal immune cells by binding to inhibitory receptors of decidual immune cells (DICs) and shifting Th1/Th2 balance toward Th2 bias. Further studies on the molecular mechanism of HLA class Ib molecules provide a reference for its application in the field of clinical assisted reproduction.
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spelling pubmed-94653352022-09-13 Advances in the study of HLA class Ib in maternal-fetal immune tolerance Yang, Yiran Wang, Wanning Weng, Jing Li, Huifang Ma, Yanmin Liu, Lingyan Ma, Wei Front Immunol Immunology The HLA class Ib molecule is an alloantigen that causes transplant rejection on behalf of individual human and plays an important role in maternal-fetal immune tolerance. Early studies on HLA class Ib focused on the mechanism of HLA-G-induced immune escape, but in recent years, studies on the mechanism of HLA-G have deepened and gradually explored the mechanism of HLA-E and HLA-F, which are also HLA class Ib molecules. In the maternal-fetal interface, trophoblast cells express HLA class Ib molecules to protect the fetus from maternal immune cells by binding to inhibitory receptors of decidual immune cells (DICs) and shifting Th1/Th2 balance toward Th2 bias. Further studies on the molecular mechanism of HLA class Ib molecules provide a reference for its application in the field of clinical assisted reproduction. Frontiers Media S.A. 2022-08-29 /pmc/articles/PMC9465335/ /pubmed/36105800 http://dx.doi.org/10.3389/fimmu.2022.976289 Text en Copyright © 2022 Yang, Wang, Weng, Li, Ma, Liu and Ma https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Yang, Yiran
Wang, Wanning
Weng, Jing
Li, Huifang
Ma, Yanmin
Liu, Lingyan
Ma, Wei
Advances in the study of HLA class Ib in maternal-fetal immune tolerance
title Advances in the study of HLA class Ib in maternal-fetal immune tolerance
title_full Advances in the study of HLA class Ib in maternal-fetal immune tolerance
title_fullStr Advances in the study of HLA class Ib in maternal-fetal immune tolerance
title_full_unstemmed Advances in the study of HLA class Ib in maternal-fetal immune tolerance
title_short Advances in the study of HLA class Ib in maternal-fetal immune tolerance
title_sort advances in the study of hla class ib in maternal-fetal immune tolerance
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9465335/
https://www.ncbi.nlm.nih.gov/pubmed/36105800
http://dx.doi.org/10.3389/fimmu.2022.976289
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