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Bombyx mori cocoon as a promising pharmacological agent: A review of ethnopharmacology, chemistry, and biological activities
Silk cocoon, naturally produced by silkworms scientifically named Bombyx mori L. (Lepidoptera, Bombycidae), is one of the well-known medicinal agents with several therapeutic activities. The present study aims to review the various aspects of the silk cocoon, including chemical composition, traditio...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9465338/ https://www.ncbi.nlm.nih.gov/pubmed/36105465 http://dx.doi.org/10.1016/j.heliyon.2022.e10496 |
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author | Biganeh, Hossein Kabiri, Mahdi Zeynalpourfattahi, Yahya Costa Brancalhão, Rose Meire Karimi, Mehrdad Shams Ardekani, Mohammad Reza Rahimi, Roja |
author_facet | Biganeh, Hossein Kabiri, Mahdi Zeynalpourfattahi, Yahya Costa Brancalhão, Rose Meire Karimi, Mehrdad Shams Ardekani, Mohammad Reza Rahimi, Roja |
author_sort | Biganeh, Hossein |
collection | PubMed |
description | Silk cocoon, naturally produced by silkworms scientifically named Bombyx mori L. (Lepidoptera, Bombycidae), is one of the well-known medicinal agents with several therapeutic activities. The present study aims to review the various aspects of the silk cocoon, including chemical composition, traditional uses, biological and biotechnological activities, and toxicological issues, to provide a scientific source for scholars. For this purpose, Electronic databases including PubMed, Scopus, Google Scholar, Web of Science, and traditional literature, were searched up to December 2021. According to the historical data, silk farming is acknowledged as one of the most ancient agricultural findings. The silk is generally composed of 75–83% fibroin, 17–25% sericin, and 1–5% non-sericin components, including secondary metabolites, wax, pigments, carbohydrates, and other impurities. Flavonoids, especially quercetin and kaempferol, alkaloids, coumarin derivatives, and phenolic acids, are among the secondary metabolites isolated from the silk cocoon. In recent years the biological properties of the silk cocoon, especially its major proteins, namely fibroin and sericin, have drawn special attention. Scientific literature has investigated several pharmacological effects of the silk cocoon and its ingredients, including cardioprotective, antioxidant, anticancer, antidiabetic, antihyperlipidemia, gastroprotective, as well as ameliorated skin health activities. In addition, it has been extensively taken into consideration in drug delivery and tissue engineering study fields. Furthermore, its toxicity is in acceptable range. |
format | Online Article Text |
id | pubmed-9465338 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-94653382022-09-13 Bombyx mori cocoon as a promising pharmacological agent: A review of ethnopharmacology, chemistry, and biological activities Biganeh, Hossein Kabiri, Mahdi Zeynalpourfattahi, Yahya Costa Brancalhão, Rose Meire Karimi, Mehrdad Shams Ardekani, Mohammad Reza Rahimi, Roja Heliyon Review Article Silk cocoon, naturally produced by silkworms scientifically named Bombyx mori L. (Lepidoptera, Bombycidae), is one of the well-known medicinal agents with several therapeutic activities. The present study aims to review the various aspects of the silk cocoon, including chemical composition, traditional uses, biological and biotechnological activities, and toxicological issues, to provide a scientific source for scholars. For this purpose, Electronic databases including PubMed, Scopus, Google Scholar, Web of Science, and traditional literature, were searched up to December 2021. According to the historical data, silk farming is acknowledged as one of the most ancient agricultural findings. The silk is generally composed of 75–83% fibroin, 17–25% sericin, and 1–5% non-sericin components, including secondary metabolites, wax, pigments, carbohydrates, and other impurities. Flavonoids, especially quercetin and kaempferol, alkaloids, coumarin derivatives, and phenolic acids, are among the secondary metabolites isolated from the silk cocoon. In recent years the biological properties of the silk cocoon, especially its major proteins, namely fibroin and sericin, have drawn special attention. Scientific literature has investigated several pharmacological effects of the silk cocoon and its ingredients, including cardioprotective, antioxidant, anticancer, antidiabetic, antihyperlipidemia, gastroprotective, as well as ameliorated skin health activities. In addition, it has been extensively taken into consideration in drug delivery and tissue engineering study fields. Furthermore, its toxicity is in acceptable range. Elsevier 2022-09-01 /pmc/articles/PMC9465338/ /pubmed/36105465 http://dx.doi.org/10.1016/j.heliyon.2022.e10496 Text en © 2022 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Article Biganeh, Hossein Kabiri, Mahdi Zeynalpourfattahi, Yahya Costa Brancalhão, Rose Meire Karimi, Mehrdad Shams Ardekani, Mohammad Reza Rahimi, Roja Bombyx mori cocoon as a promising pharmacological agent: A review of ethnopharmacology, chemistry, and biological activities |
title | Bombyx mori cocoon as a promising pharmacological agent: A review of ethnopharmacology, chemistry, and biological activities |
title_full | Bombyx mori cocoon as a promising pharmacological agent: A review of ethnopharmacology, chemistry, and biological activities |
title_fullStr | Bombyx mori cocoon as a promising pharmacological agent: A review of ethnopharmacology, chemistry, and biological activities |
title_full_unstemmed | Bombyx mori cocoon as a promising pharmacological agent: A review of ethnopharmacology, chemistry, and biological activities |
title_short | Bombyx mori cocoon as a promising pharmacological agent: A review of ethnopharmacology, chemistry, and biological activities |
title_sort | bombyx mori cocoon as a promising pharmacological agent: a review of ethnopharmacology, chemistry, and biological activities |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9465338/ https://www.ncbi.nlm.nih.gov/pubmed/36105465 http://dx.doi.org/10.1016/j.heliyon.2022.e10496 |
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