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Bombyx mori cocoon as a promising pharmacological agent: A review of ethnopharmacology, chemistry, and biological activities

Silk cocoon, naturally produced by silkworms scientifically named Bombyx mori L. (Lepidoptera, Bombycidae), is one of the well-known medicinal agents with several therapeutic activities. The present study aims to review the various aspects of the silk cocoon, including chemical composition, traditio...

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Autores principales: Biganeh, Hossein, Kabiri, Mahdi, Zeynalpourfattahi, Yahya, Costa Brancalhão, Rose Meire, Karimi, Mehrdad, Shams Ardekani, Mohammad Reza, Rahimi, Roja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9465338/
https://www.ncbi.nlm.nih.gov/pubmed/36105465
http://dx.doi.org/10.1016/j.heliyon.2022.e10496
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author Biganeh, Hossein
Kabiri, Mahdi
Zeynalpourfattahi, Yahya
Costa Brancalhão, Rose Meire
Karimi, Mehrdad
Shams Ardekani, Mohammad Reza
Rahimi, Roja
author_facet Biganeh, Hossein
Kabiri, Mahdi
Zeynalpourfattahi, Yahya
Costa Brancalhão, Rose Meire
Karimi, Mehrdad
Shams Ardekani, Mohammad Reza
Rahimi, Roja
author_sort Biganeh, Hossein
collection PubMed
description Silk cocoon, naturally produced by silkworms scientifically named Bombyx mori L. (Lepidoptera, Bombycidae), is one of the well-known medicinal agents with several therapeutic activities. The present study aims to review the various aspects of the silk cocoon, including chemical composition, traditional uses, biological and biotechnological activities, and toxicological issues, to provide a scientific source for scholars. For this purpose, Electronic databases including PubMed, Scopus, Google Scholar, Web of Science, and traditional literature, were searched up to December 2021. According to the historical data, silk farming is acknowledged as one of the most ancient agricultural findings. The silk is generally composed of 75–83% fibroin, 17–25% sericin, and 1–5% non-sericin components, including secondary metabolites, wax, pigments, carbohydrates, and other impurities. Flavonoids, especially quercetin and kaempferol, alkaloids, coumarin derivatives, and phenolic acids, are among the secondary metabolites isolated from the silk cocoon. In recent years the biological properties of the silk cocoon, especially its major proteins, namely fibroin and sericin, have drawn special attention. Scientific literature has investigated several pharmacological effects of the silk cocoon and its ingredients, including cardioprotective, antioxidant, anticancer, antidiabetic, antihyperlipidemia, gastroprotective, as well as ameliorated skin health activities. In addition, it has been extensively taken into consideration in drug delivery and tissue engineering study fields. Furthermore, its toxicity is in acceptable range.
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spelling pubmed-94653382022-09-13 Bombyx mori cocoon as a promising pharmacological agent: A review of ethnopharmacology, chemistry, and biological activities Biganeh, Hossein Kabiri, Mahdi Zeynalpourfattahi, Yahya Costa Brancalhão, Rose Meire Karimi, Mehrdad Shams Ardekani, Mohammad Reza Rahimi, Roja Heliyon Review Article Silk cocoon, naturally produced by silkworms scientifically named Bombyx mori L. (Lepidoptera, Bombycidae), is one of the well-known medicinal agents with several therapeutic activities. The present study aims to review the various aspects of the silk cocoon, including chemical composition, traditional uses, biological and biotechnological activities, and toxicological issues, to provide a scientific source for scholars. For this purpose, Electronic databases including PubMed, Scopus, Google Scholar, Web of Science, and traditional literature, were searched up to December 2021. According to the historical data, silk farming is acknowledged as one of the most ancient agricultural findings. The silk is generally composed of 75–83% fibroin, 17–25% sericin, and 1–5% non-sericin components, including secondary metabolites, wax, pigments, carbohydrates, and other impurities. Flavonoids, especially quercetin and kaempferol, alkaloids, coumarin derivatives, and phenolic acids, are among the secondary metabolites isolated from the silk cocoon. In recent years the biological properties of the silk cocoon, especially its major proteins, namely fibroin and sericin, have drawn special attention. Scientific literature has investigated several pharmacological effects of the silk cocoon and its ingredients, including cardioprotective, antioxidant, anticancer, antidiabetic, antihyperlipidemia, gastroprotective, as well as ameliorated skin health activities. In addition, it has been extensively taken into consideration in drug delivery and tissue engineering study fields. Furthermore, its toxicity is in acceptable range. Elsevier 2022-09-01 /pmc/articles/PMC9465338/ /pubmed/36105465 http://dx.doi.org/10.1016/j.heliyon.2022.e10496 Text en © 2022 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review Article
Biganeh, Hossein
Kabiri, Mahdi
Zeynalpourfattahi, Yahya
Costa Brancalhão, Rose Meire
Karimi, Mehrdad
Shams Ardekani, Mohammad Reza
Rahimi, Roja
Bombyx mori cocoon as a promising pharmacological agent: A review of ethnopharmacology, chemistry, and biological activities
title Bombyx mori cocoon as a promising pharmacological agent: A review of ethnopharmacology, chemistry, and biological activities
title_full Bombyx mori cocoon as a promising pharmacological agent: A review of ethnopharmacology, chemistry, and biological activities
title_fullStr Bombyx mori cocoon as a promising pharmacological agent: A review of ethnopharmacology, chemistry, and biological activities
title_full_unstemmed Bombyx mori cocoon as a promising pharmacological agent: A review of ethnopharmacology, chemistry, and biological activities
title_short Bombyx mori cocoon as a promising pharmacological agent: A review of ethnopharmacology, chemistry, and biological activities
title_sort bombyx mori cocoon as a promising pharmacological agent: a review of ethnopharmacology, chemistry, and biological activities
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9465338/
https://www.ncbi.nlm.nih.gov/pubmed/36105465
http://dx.doi.org/10.1016/j.heliyon.2022.e10496
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