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Exploring the mechanism of action of dapansutrile in the treatment of gouty arthritis based on molecular docking and molecular dynamics

Purpose: Dapansutrile is an orally active β-sulfonyl nitrile compound that selectively inhibits the NLRP3 inflammasome. Clinical studies have shown that dapansutrile is active in vivo and limits the severity of endotoxin-induced inflammation and joint arthritis. However, there is currently a lack of...

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Detalles Bibliográficos
Autores principales:	Cao, Jun-Feng, Xingyu Yang, Li Xiong, Wu, Mei, Chen, Shengyan, Xu, Hengxiang, Gong, Yunli, Zhang, Lixin, Zhang, Qilan, Zhang, Xiao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9465377/ https://www.ncbi.nlm.nih.gov/pubmed/36105284 http://dx.doi.org/10.3389/fphys.2022.990469

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