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Reprogramming lipid metabolism as potential strategy for hematological malignancy therapy
Hematological malignancies are one of the most lethal illnesses that seriously threaten human life and health. Lipids are important constituents of various biological membranes and substances for energy storage and cell signaling. Furthermore, lipids are critical in the normal physiological activiti...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9465383/ https://www.ncbi.nlm.nih.gov/pubmed/36106108 http://dx.doi.org/10.3389/fonc.2022.987499 |
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author | Zhang, Leqiang Chang, Ning Liu, Jia Liu, Zhuojun Wu, Yajin Sui, Linlin Chen, Wei |
author_facet | Zhang, Leqiang Chang, Ning Liu, Jia Liu, Zhuojun Wu, Yajin Sui, Linlin Chen, Wei |
author_sort | Zhang, Leqiang |
collection | PubMed |
description | Hematological malignancies are one of the most lethal illnesses that seriously threaten human life and health. Lipids are important constituents of various biological membranes and substances for energy storage and cell signaling. Furthermore, lipids are critical in the normal physiological activities of cells. In the process of the lethal transformation of hematological malignancies, lipid metabolism reprogramming meets the material and energy requirements of rapidly proliferating and dividing tumor cells. A large number of studies have shown that dysregulated lipid metabolism, commonly occurs in hematological malignancies, mediating the proliferation, growth, migration, invasion, apoptosis, drug resistance and immune escape of tumor cells. Targeting the lipid metabolism pathway of hematological malignancies has become an effective therapeutic approach. This article reviews the oncogenic mechanisms of lipid metabolism reprogramming in hematological malignancies, including fatty acid, cholesterol and phospholipid metabolism, thereby offering an insight into targeting lipid metabolism in the treatment of hematological malignancies. |
format | Online Article Text |
id | pubmed-9465383 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94653832022-09-13 Reprogramming lipid metabolism as potential strategy for hematological malignancy therapy Zhang, Leqiang Chang, Ning Liu, Jia Liu, Zhuojun Wu, Yajin Sui, Linlin Chen, Wei Front Oncol Oncology Hematological malignancies are one of the most lethal illnesses that seriously threaten human life and health. Lipids are important constituents of various biological membranes and substances for energy storage and cell signaling. Furthermore, lipids are critical in the normal physiological activities of cells. In the process of the lethal transformation of hematological malignancies, lipid metabolism reprogramming meets the material and energy requirements of rapidly proliferating and dividing tumor cells. A large number of studies have shown that dysregulated lipid metabolism, commonly occurs in hematological malignancies, mediating the proliferation, growth, migration, invasion, apoptosis, drug resistance and immune escape of tumor cells. Targeting the lipid metabolism pathway of hematological malignancies has become an effective therapeutic approach. This article reviews the oncogenic mechanisms of lipid metabolism reprogramming in hematological malignancies, including fatty acid, cholesterol and phospholipid metabolism, thereby offering an insight into targeting lipid metabolism in the treatment of hematological malignancies. Frontiers Media S.A. 2022-08-29 /pmc/articles/PMC9465383/ /pubmed/36106108 http://dx.doi.org/10.3389/fonc.2022.987499 Text en Copyright © 2022 Zhang, Chang, Liu, Liu, Wu, Sui and Chen https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Zhang, Leqiang Chang, Ning Liu, Jia Liu, Zhuojun Wu, Yajin Sui, Linlin Chen, Wei Reprogramming lipid metabolism as potential strategy for hematological malignancy therapy |
title | Reprogramming lipid metabolism as potential strategy for hematological malignancy therapy |
title_full | Reprogramming lipid metabolism as potential strategy for hematological malignancy therapy |
title_fullStr | Reprogramming lipid metabolism as potential strategy for hematological malignancy therapy |
title_full_unstemmed | Reprogramming lipid metabolism as potential strategy for hematological malignancy therapy |
title_short | Reprogramming lipid metabolism as potential strategy for hematological malignancy therapy |
title_sort | reprogramming lipid metabolism as potential strategy for hematological malignancy therapy |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9465383/ https://www.ncbi.nlm.nih.gov/pubmed/36106108 http://dx.doi.org/10.3389/fonc.2022.987499 |
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