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Interhemispheric asymmetry of the brain in patients with type 1 diabetes mellitus and cognitive impairment

With an ageing of population and a splurging epidemic of diabetes mellitus (DM), the prevalence of complications associated with pathology of the central nervous system are expected to increase, which in the future may have serious consequences for public health. It is known that one of the main man...

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Autores principales: Samoilova, Yulia Gennadevna, Matveeva, Mariia Vladimirovna, Tonkih, Olga Sergeevna, Kudlay, Dmitry Anatolievich, Oleynik, Oxana Alekseevna, Aremu, Stephen Olaide, Kilina, Oksana Yurievna, Kanev, Alexander Federovich, Gerget, Olga Mihailovna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9465454/
https://www.ncbi.nlm.nih.gov/pubmed/36105393
http://dx.doi.org/10.3389/fendo.2022.961254
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author Samoilova, Yulia Gennadevna
Matveeva, Mariia Vladimirovna
Tonkih, Olga Sergeevna
Kudlay, Dmitry Anatolievich
Oleynik, Oxana Alekseevna
Aremu, Stephen Olaide
Kilina, Oksana Yurievna
Kanev, Alexander Federovich
Gerget, Olga Mihailovna
author_facet Samoilova, Yulia Gennadevna
Matveeva, Mariia Vladimirovna
Tonkih, Olga Sergeevna
Kudlay, Dmitry Anatolievich
Oleynik, Oxana Alekseevna
Aremu, Stephen Olaide
Kilina, Oksana Yurievna
Kanev, Alexander Federovich
Gerget, Olga Mihailovna
author_sort Samoilova, Yulia Gennadevna
collection PubMed
description With an ageing of population and a splurging epidemic of diabetes mellitus (DM), the prevalence of complications associated with pathology of the central nervous system are expected to increase, which in the future may have serious consequences for public health. It is known that one of the main manifestations of brain damage in type 1 diabetes is cognitive impairment, which is possibly associated with the peculiarities of vascularization and interhemispheric asymmetry, which requires in-depth analysis using modern neuroimaging methods. The aim of the study is to assess the symmetry of structural, metabolic and neurovascularization changes in the brain in patients with type 1 diabetes and cognitive impairment. The study included 120 patients with type 1 diabetes aged 18 to 45 years suffering from cognitive impairment, and 30 people without cognitive decline and the control group (n=30) healthy people without diabetes. Neuropsychological testing included the Montreal Cognitive Dysfunction Assessment Scale (MoCA test). For neuroimaging methods, standard magnetic resonance imaging (MRI), magnetic resonance spectroscopy (MRS), contrast and non-contrast-enhanced perfusion were used. Statistical processing was carried out using the SPSS Statistic 2020 software. In patients with type 1 diabetes with cognitive impairment, as manifested by impaired memory and/or attention, perfusion imaging revealed the presence of brain asymmetry zones. Standard MRI allowed to demonstrate changes in the white, gray matter and hippocampus in the right hemisphere. The results obtained were refined taking into account the topical localization, so during the perfusion study, regions with asymmetric blood flow were identified - namely, the white matter of the frontal lobe and the gray matter in the occipital lobe. Spectroscopy of the brain revealed that it was in these areas of the brain that the most significant metabolic disorders were noted – in the form of significantly altered ratio of N-acetylaspartate (NAA)/choline (Cho) on the left, along with the asymmetry in phosphocreatine level (Cr 2) on the right. In conclusion, early preclinical predictive diagnostics with the use of modern neuroimaging methods allows for timely detection of impaired vascularization and brain metabolism in this group of patients, However, decreased perfusion in the region within the region of frontal lobe white matter and temporal lobe grey matter, and hippocampal cell metabolism by spectra should be highlighted among the parameters Cr right and NAA/Cho left.
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spelling pubmed-94654542022-09-13 Interhemispheric asymmetry of the brain in patients with type 1 diabetes mellitus and cognitive impairment Samoilova, Yulia Gennadevna Matveeva, Mariia Vladimirovna Tonkih, Olga Sergeevna Kudlay, Dmitry Anatolievich Oleynik, Oxana Alekseevna Aremu, Stephen Olaide Kilina, Oksana Yurievna Kanev, Alexander Federovich Gerget, Olga Mihailovna Front Endocrinol (Lausanne) Endocrinology With an ageing of population and a splurging epidemic of diabetes mellitus (DM), the prevalence of complications associated with pathology of the central nervous system are expected to increase, which in the future may have serious consequences for public health. It is known that one of the main manifestations of brain damage in type 1 diabetes is cognitive impairment, which is possibly associated with the peculiarities of vascularization and interhemispheric asymmetry, which requires in-depth analysis using modern neuroimaging methods. The aim of the study is to assess the symmetry of structural, metabolic and neurovascularization changes in the brain in patients with type 1 diabetes and cognitive impairment. The study included 120 patients with type 1 diabetes aged 18 to 45 years suffering from cognitive impairment, and 30 people without cognitive decline and the control group (n=30) healthy people without diabetes. Neuropsychological testing included the Montreal Cognitive Dysfunction Assessment Scale (MoCA test). For neuroimaging methods, standard magnetic resonance imaging (MRI), magnetic resonance spectroscopy (MRS), contrast and non-contrast-enhanced perfusion were used. Statistical processing was carried out using the SPSS Statistic 2020 software. In patients with type 1 diabetes with cognitive impairment, as manifested by impaired memory and/or attention, perfusion imaging revealed the presence of brain asymmetry zones. Standard MRI allowed to demonstrate changes in the white, gray matter and hippocampus in the right hemisphere. The results obtained were refined taking into account the topical localization, so during the perfusion study, regions with asymmetric blood flow were identified - namely, the white matter of the frontal lobe and the gray matter in the occipital lobe. Spectroscopy of the brain revealed that it was in these areas of the brain that the most significant metabolic disorders were noted – in the form of significantly altered ratio of N-acetylaspartate (NAA)/choline (Cho) on the left, along with the asymmetry in phosphocreatine level (Cr 2) on the right. In conclusion, early preclinical predictive diagnostics with the use of modern neuroimaging methods allows for timely detection of impaired vascularization and brain metabolism in this group of patients, However, decreased perfusion in the region within the region of frontal lobe white matter and temporal lobe grey matter, and hippocampal cell metabolism by spectra should be highlighted among the parameters Cr right and NAA/Cho left. Frontiers Media S.A. 2022-08-29 /pmc/articles/PMC9465454/ /pubmed/36105393 http://dx.doi.org/10.3389/fendo.2022.961254 Text en Copyright © 2022 Samoilova, Matveeva, Tonkih, Kudlay, Oleynik, Aremu, Kilina, Kanev and Gerget https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Samoilova, Yulia Gennadevna
Matveeva, Mariia Vladimirovna
Tonkih, Olga Sergeevna
Kudlay, Dmitry Anatolievich
Oleynik, Oxana Alekseevna
Aremu, Stephen Olaide
Kilina, Oksana Yurievna
Kanev, Alexander Federovich
Gerget, Olga Mihailovna
Interhemispheric asymmetry of the brain in patients with type 1 diabetes mellitus and cognitive impairment
title Interhemispheric asymmetry of the brain in patients with type 1 diabetes mellitus and cognitive impairment
title_full Interhemispheric asymmetry of the brain in patients with type 1 diabetes mellitus and cognitive impairment
title_fullStr Interhemispheric asymmetry of the brain in patients with type 1 diabetes mellitus and cognitive impairment
title_full_unstemmed Interhemispheric asymmetry of the brain in patients with type 1 diabetes mellitus and cognitive impairment
title_short Interhemispheric asymmetry of the brain in patients with type 1 diabetes mellitus and cognitive impairment
title_sort interhemispheric asymmetry of the brain in patients with type 1 diabetes mellitus and cognitive impairment
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9465454/
https://www.ncbi.nlm.nih.gov/pubmed/36105393
http://dx.doi.org/10.3389/fendo.2022.961254
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