Cargando…
Interhemispheric asymmetry of the brain in patients with type 1 diabetes mellitus and cognitive impairment
With an ageing of population and a splurging epidemic of diabetes mellitus (DM), the prevalence of complications associated with pathology of the central nervous system are expected to increase, which in the future may have serious consequences for public health. It is known that one of the main man...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9465454/ https://www.ncbi.nlm.nih.gov/pubmed/36105393 http://dx.doi.org/10.3389/fendo.2022.961254 |
_version_ | 1784787800599560192 |
---|---|
author | Samoilova, Yulia Gennadevna Matveeva, Mariia Vladimirovna Tonkih, Olga Sergeevna Kudlay, Dmitry Anatolievich Oleynik, Oxana Alekseevna Aremu, Stephen Olaide Kilina, Oksana Yurievna Kanev, Alexander Federovich Gerget, Olga Mihailovna |
author_facet | Samoilova, Yulia Gennadevna Matveeva, Mariia Vladimirovna Tonkih, Olga Sergeevna Kudlay, Dmitry Anatolievich Oleynik, Oxana Alekseevna Aremu, Stephen Olaide Kilina, Oksana Yurievna Kanev, Alexander Federovich Gerget, Olga Mihailovna |
author_sort | Samoilova, Yulia Gennadevna |
collection | PubMed |
description | With an ageing of population and a splurging epidemic of diabetes mellitus (DM), the prevalence of complications associated with pathology of the central nervous system are expected to increase, which in the future may have serious consequences for public health. It is known that one of the main manifestations of brain damage in type 1 diabetes is cognitive impairment, which is possibly associated with the peculiarities of vascularization and interhemispheric asymmetry, which requires in-depth analysis using modern neuroimaging methods. The aim of the study is to assess the symmetry of structural, metabolic and neurovascularization changes in the brain in patients with type 1 diabetes and cognitive impairment. The study included 120 patients with type 1 diabetes aged 18 to 45 years suffering from cognitive impairment, and 30 people without cognitive decline and the control group (n=30) healthy people without diabetes. Neuropsychological testing included the Montreal Cognitive Dysfunction Assessment Scale (MoCA test). For neuroimaging methods, standard magnetic resonance imaging (MRI), magnetic resonance spectroscopy (MRS), contrast and non-contrast-enhanced perfusion were used. Statistical processing was carried out using the SPSS Statistic 2020 software. In patients with type 1 diabetes with cognitive impairment, as manifested by impaired memory and/or attention, perfusion imaging revealed the presence of brain asymmetry zones. Standard MRI allowed to demonstrate changes in the white, gray matter and hippocampus in the right hemisphere. The results obtained were refined taking into account the topical localization, so during the perfusion study, regions with asymmetric blood flow were identified - namely, the white matter of the frontal lobe and the gray matter in the occipital lobe. Spectroscopy of the brain revealed that it was in these areas of the brain that the most significant metabolic disorders were noted – in the form of significantly altered ratio of N-acetylaspartate (NAA)/choline (Cho) on the left, along with the asymmetry in phosphocreatine level (Cr 2) on the right. In conclusion, early preclinical predictive diagnostics with the use of modern neuroimaging methods allows for timely detection of impaired vascularization and brain metabolism in this group of patients, However, decreased perfusion in the region within the region of frontal lobe white matter and temporal lobe grey matter, and hippocampal cell metabolism by spectra should be highlighted among the parameters Cr right and NAA/Cho left. |
format | Online Article Text |
id | pubmed-9465454 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94654542022-09-13 Interhemispheric asymmetry of the brain in patients with type 1 diabetes mellitus and cognitive impairment Samoilova, Yulia Gennadevna Matveeva, Mariia Vladimirovna Tonkih, Olga Sergeevna Kudlay, Dmitry Anatolievich Oleynik, Oxana Alekseevna Aremu, Stephen Olaide Kilina, Oksana Yurievna Kanev, Alexander Federovich Gerget, Olga Mihailovna Front Endocrinol (Lausanne) Endocrinology With an ageing of population and a splurging epidemic of diabetes mellitus (DM), the prevalence of complications associated with pathology of the central nervous system are expected to increase, which in the future may have serious consequences for public health. It is known that one of the main manifestations of brain damage in type 1 diabetes is cognitive impairment, which is possibly associated with the peculiarities of vascularization and interhemispheric asymmetry, which requires in-depth analysis using modern neuroimaging methods. The aim of the study is to assess the symmetry of structural, metabolic and neurovascularization changes in the brain in patients with type 1 diabetes and cognitive impairment. The study included 120 patients with type 1 diabetes aged 18 to 45 years suffering from cognitive impairment, and 30 people without cognitive decline and the control group (n=30) healthy people without diabetes. Neuropsychological testing included the Montreal Cognitive Dysfunction Assessment Scale (MoCA test). For neuroimaging methods, standard magnetic resonance imaging (MRI), magnetic resonance spectroscopy (MRS), contrast and non-contrast-enhanced perfusion were used. Statistical processing was carried out using the SPSS Statistic 2020 software. In patients with type 1 diabetes with cognitive impairment, as manifested by impaired memory and/or attention, perfusion imaging revealed the presence of brain asymmetry zones. Standard MRI allowed to demonstrate changes in the white, gray matter and hippocampus in the right hemisphere. The results obtained were refined taking into account the topical localization, so during the perfusion study, regions with asymmetric blood flow were identified - namely, the white matter of the frontal lobe and the gray matter in the occipital lobe. Spectroscopy of the brain revealed that it was in these areas of the brain that the most significant metabolic disorders were noted – in the form of significantly altered ratio of N-acetylaspartate (NAA)/choline (Cho) on the left, along with the asymmetry in phosphocreatine level (Cr 2) on the right. In conclusion, early preclinical predictive diagnostics with the use of modern neuroimaging methods allows for timely detection of impaired vascularization and brain metabolism in this group of patients, However, decreased perfusion in the region within the region of frontal lobe white matter and temporal lobe grey matter, and hippocampal cell metabolism by spectra should be highlighted among the parameters Cr right and NAA/Cho left. Frontiers Media S.A. 2022-08-29 /pmc/articles/PMC9465454/ /pubmed/36105393 http://dx.doi.org/10.3389/fendo.2022.961254 Text en Copyright © 2022 Samoilova, Matveeva, Tonkih, Kudlay, Oleynik, Aremu, Kilina, Kanev and Gerget https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Samoilova, Yulia Gennadevna Matveeva, Mariia Vladimirovna Tonkih, Olga Sergeevna Kudlay, Dmitry Anatolievich Oleynik, Oxana Alekseevna Aremu, Stephen Olaide Kilina, Oksana Yurievna Kanev, Alexander Federovich Gerget, Olga Mihailovna Interhemispheric asymmetry of the brain in patients with type 1 diabetes mellitus and cognitive impairment |
title | Interhemispheric asymmetry of the brain in patients with type 1 diabetes mellitus and cognitive impairment |
title_full | Interhemispheric asymmetry of the brain in patients with type 1 diabetes mellitus and cognitive impairment |
title_fullStr | Interhemispheric asymmetry of the brain in patients with type 1 diabetes mellitus and cognitive impairment |
title_full_unstemmed | Interhemispheric asymmetry of the brain in patients with type 1 diabetes mellitus and cognitive impairment |
title_short | Interhemispheric asymmetry of the brain in patients with type 1 diabetes mellitus and cognitive impairment |
title_sort | interhemispheric asymmetry of the brain in patients with type 1 diabetes mellitus and cognitive impairment |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9465454/ https://www.ncbi.nlm.nih.gov/pubmed/36105393 http://dx.doi.org/10.3389/fendo.2022.961254 |
work_keys_str_mv | AT samoilovayuliagennadevna interhemisphericasymmetryofthebraininpatientswithtype1diabetesmellitusandcognitiveimpairment AT matveevamariiavladimirovna interhemisphericasymmetryofthebraininpatientswithtype1diabetesmellitusandcognitiveimpairment AT tonkiholgasergeevna interhemisphericasymmetryofthebraininpatientswithtype1diabetesmellitusandcognitiveimpairment AT kudlaydmitryanatolievich interhemisphericasymmetryofthebraininpatientswithtype1diabetesmellitusandcognitiveimpairment AT oleynikoxanaalekseevna interhemisphericasymmetryofthebraininpatientswithtype1diabetesmellitusandcognitiveimpairment AT aremustephenolaide interhemisphericasymmetryofthebraininpatientswithtype1diabetesmellitusandcognitiveimpairment AT kilinaoksanayurievna interhemisphericasymmetryofthebraininpatientswithtype1diabetesmellitusandcognitiveimpairment AT kanevalexanderfederovich interhemisphericasymmetryofthebraininpatientswithtype1diabetesmellitusandcognitiveimpairment AT gergetolgamihailovna interhemisphericasymmetryofthebraininpatientswithtype1diabetesmellitusandcognitiveimpairment |