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Investigating brain uptake of a non-targeting monoclonal antibody after intravenous and intracerebroventricular administration

Monoclonal antibodies play an important role in the treatment of various diseases. However, the development of these drugs against neurological disorders where the drug target is located in the brain is challenging and requires a good understanding of the local drug concentration in the brain. In th...

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Detalles Bibliográficos
Autores principales:	Van De Vyver, Arthur J., Walz, Antje-Christine, Heins, Mariette S., Abdolzade-Bavil, Afsaneh, Kraft, Thomas E., Waldhauer, Inja, Otteneder, Michael B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9465605/ https://www.ncbi.nlm.nih.gov/pubmed/36105215 http://dx.doi.org/10.3389/fphar.2022.958543

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