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Identification of α-Synuclein Proaggregator: Rapid Synthesis and Streamlining RT-QuIC Assays in Parkinson’s Disease

[Image: see text] We report the discovery of two compounds, TKD150 and TKD152, that promote the aggregation of α-synuclein (aSN) using a real-time quaking-induced conversion (RT-QuIC) assay to detect abnormal aSN. By utilizing a Pd-catalyzed C–H arylation of benzoxazole with iodoarenes and implement...

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Detalles Bibliográficos
Autores principales:	Takada, Fumito, Kasahara, Takahito, Otake, Kentaro, Maru, Takamitsu, Miwa, Masanori, Muto, Kei, Sasaki, Minoru, Hirozane, Yoshihiko, Yoshikawa, Masato, Yamaguchi, Junichiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9465709/ https://www.ncbi.nlm.nih.gov/pubmed/36105342 http://dx.doi.org/10.1021/acsmedchemlett.2c00138

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