Identification of a BAZ2A-Bromodomain Hit Compound by Fragment Growing

[Image: see text] BAZ2A is an epigenetic regulator affecting transcription of ribosomal RNA. It is overexpressed in aggressive and recurrent prostate cancer, promoting cellular migration. Its bromodomain is characterized by a shallow and difficult-to-drug pocket. Here, we describe a structure-based...

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Detalles Bibliográficos
Autores principales: Dalle Vedove, Andrea, Cazzanelli, Giulia, Batiste, Laurent, Marchand, Jean-Rémy, Spiliotopoulos, Dimitrios, Corsi, Jessica, D’Agostino, Vito Giuseppe, Caflisch, Amedeo, Lolli, Graziano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9465710/
https://www.ncbi.nlm.nih.gov/pubmed/36105334
http://dx.doi.org/10.1021/acsmedchemlett.2c00173

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9465710/
https://www.ncbi.nlm.nih.gov/pubmed/36105334
http://dx.doi.org/10.1021/acsmedchemlett.2c00173

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