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Identification of a BAZ2A-Bromodomain Hit Compound by Fragment Growing
[Image: see text] BAZ2A is an epigenetic regulator affecting transcription of ribosomal RNA. It is overexpressed in aggressive and recurrent prostate cancer, promoting cellular migration. Its bromodomain is characterized by a shallow and difficult-to-drug pocket. Here, we describe a structure-based...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9465710/ https://www.ncbi.nlm.nih.gov/pubmed/36105334 http://dx.doi.org/10.1021/acsmedchemlett.2c00173 |