Molecular convergence between Down syndrome and fragile X syndrome identified using human pluripotent stem cell models

Down syndrome (DS), driven by an extra copy of chromosome 21 (HSA21), and fragile X syndrome (FXS), driven by loss of the RNA-binding protein FMRP, are two common genetic causes of intellectual disability and autism. Based upon the number of DS-implicated transcripts bound by FMRP, we hypothesize th...

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Detalles Bibliográficos
Autores principales: Susco, Sara G., Ghosh, Sulagna, Mazzucato, Patrizia, Angelini, Gabriella, Beccard, Amanda, Barrera, Victor, Berryer, Martin H., Messana, Angelica, Lam, Daisy, Hazelbaker, Dane Z., Barrett, Lindy E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9465809/
https://www.ncbi.nlm.nih.gov/pubmed/36070702
http://dx.doi.org/10.1016/j.celrep.2022.111312

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