Comparative analyses of vertebrate CPEB proteins define two subfamilies with coordinated yet distinct functions in post-transcriptional gene regulation

BACKGROUND: Vertebrate CPEB proteins bind mRNAs at cytoplasmic polyadenylation elements (CPEs) in their 3′ UTRs, leading to cytoplasmic changes in their poly(A) tail lengths; this can promote translational repression or activation of the mRNA. However, neither the regulation nor the mechanisms of ac...

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Detalles Bibliográficos
Autores principales: Duran-Arqué, Berta, Cañete, Manuel, Castellazzi, Chiara Lara, Bartomeu, Anna, Ferrer-Caelles, Anna, Reina, Oscar, Caballé, Adrià, Gay, Marina, Arauz-Garofalo, Gianluca, Belloc, Eulalia, Mendez, Raúl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9465852/
https://www.ncbi.nlm.nih.gov/pubmed/36096799
http://dx.doi.org/10.1186/s13059-022-02759-y

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