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Probiotic effects on sexual function in women with polycystic ovary syndrome: a double blinded randomized controlled trial

BACKGROUND: Considering the presence of sexual dysfunction in patients with polycystic ovary syndrome, our aim was to provide scientific evidence studying effect of oral probiotic on sexual function in patients with PCOS treated with letrozole in an Iranian population. METHODS: This study was a doub...

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Autores principales: Azizi-Kutenaee, Maryam, Heidari, Solmaz, Taghavi, Seyed-Abdolvahab, Bazarganipour, Fatemeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9465857/
https://www.ncbi.nlm.nih.gov/pubmed/36096842
http://dx.doi.org/10.1186/s12905-022-01955-z
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author Azizi-Kutenaee, Maryam
Heidari, Solmaz
Taghavi, Seyed-Abdolvahab
Bazarganipour, Fatemeh
author_facet Azizi-Kutenaee, Maryam
Heidari, Solmaz
Taghavi, Seyed-Abdolvahab
Bazarganipour, Fatemeh
author_sort Azizi-Kutenaee, Maryam
collection PubMed
description BACKGROUND: Considering the presence of sexual dysfunction in patients with polycystic ovary syndrome, our aim was to provide scientific evidence studying effect of oral probiotic on sexual function in patients with PCOS treated with letrozole in an Iranian population. METHODS: This study was a double blind randomized clinical trial. Eligible women were allocated to Lactofem plus letrozole (n = 20) or letrozole (n = 20). Folic acid was prescribed to all participants in two groups during the study. In group A, Lactofem capsule was administered daily for the first month. In the second month, letrozole (2.5 mg daily from the third day of the menstrual cycle for 5 days) plus Lactofem capsule same as previous month were prescribed. In group B, letrozole administered 2.5 days from the third day of the menstrual cycle for 5 days in the second month. All questionnaires were completed by patients after the intervention (two months after the start of treatment). The Female Sexual Function Index (FSFI) and Body Image Concern Inventory (BICI) were used to assess sexual function and body satisfaction, respectively. RESULTS: There is statistically significant increase in chemical pregnancy rate (10% vs. 0%; p = 0.05) and clinical pregnancy (10% vs. 0%; p = 0.05) in Probiotic plus letrozole group compared to letrozole group after intervention. Based on our results, there was a statistically significant difference in each domain and sum score of sexual function of before and after the intervention between group (P < 0.05). Our findings have been shown, after eight weeks, the probiotic plus letrozole group had a significant improvement in the FSFI domains and sum score compared to letrozole alone group. Moreover, there are a significant improvement in mean (IQR) of body image score in probiotic group [30 (4.99) vs. 40 (4.36); P < 0.01]. CONCLUSION: The results of the current study suggests that eight weeks of administration of probiotic may improve chemical and clinical pregnancy rate, sexual function and body satisfaction in women with PCOS.
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spelling pubmed-94658572022-09-13 Probiotic effects on sexual function in women with polycystic ovary syndrome: a double blinded randomized controlled trial Azizi-Kutenaee, Maryam Heidari, Solmaz Taghavi, Seyed-Abdolvahab Bazarganipour, Fatemeh BMC Womens Health Research BACKGROUND: Considering the presence of sexual dysfunction in patients with polycystic ovary syndrome, our aim was to provide scientific evidence studying effect of oral probiotic on sexual function in patients with PCOS treated with letrozole in an Iranian population. METHODS: This study was a double blind randomized clinical trial. Eligible women were allocated to Lactofem plus letrozole (n = 20) or letrozole (n = 20). Folic acid was prescribed to all participants in two groups during the study. In group A, Lactofem capsule was administered daily for the first month. In the second month, letrozole (2.5 mg daily from the third day of the menstrual cycle for 5 days) plus Lactofem capsule same as previous month were prescribed. In group B, letrozole administered 2.5 days from the third day of the menstrual cycle for 5 days in the second month. All questionnaires were completed by patients after the intervention (two months after the start of treatment). The Female Sexual Function Index (FSFI) and Body Image Concern Inventory (BICI) were used to assess sexual function and body satisfaction, respectively. RESULTS: There is statistically significant increase in chemical pregnancy rate (10% vs. 0%; p = 0.05) and clinical pregnancy (10% vs. 0%; p = 0.05) in Probiotic plus letrozole group compared to letrozole group after intervention. Based on our results, there was a statistically significant difference in each domain and sum score of sexual function of before and after the intervention between group (P < 0.05). Our findings have been shown, after eight weeks, the probiotic plus letrozole group had a significant improvement in the FSFI domains and sum score compared to letrozole alone group. Moreover, there are a significant improvement in mean (IQR) of body image score in probiotic group [30 (4.99) vs. 40 (4.36); P < 0.01]. CONCLUSION: The results of the current study suggests that eight weeks of administration of probiotic may improve chemical and clinical pregnancy rate, sexual function and body satisfaction in women with PCOS. BioMed Central 2022-09-12 /pmc/articles/PMC9465857/ /pubmed/36096842 http://dx.doi.org/10.1186/s12905-022-01955-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Azizi-Kutenaee, Maryam
Heidari, Solmaz
Taghavi, Seyed-Abdolvahab
Bazarganipour, Fatemeh
Probiotic effects on sexual function in women with polycystic ovary syndrome: a double blinded randomized controlled trial
title Probiotic effects on sexual function in women with polycystic ovary syndrome: a double blinded randomized controlled trial
title_full Probiotic effects on sexual function in women with polycystic ovary syndrome: a double blinded randomized controlled trial
title_fullStr Probiotic effects on sexual function in women with polycystic ovary syndrome: a double blinded randomized controlled trial
title_full_unstemmed Probiotic effects on sexual function in women with polycystic ovary syndrome: a double blinded randomized controlled trial
title_short Probiotic effects on sexual function in women with polycystic ovary syndrome: a double blinded randomized controlled trial
title_sort probiotic effects on sexual function in women with polycystic ovary syndrome: a double blinded randomized controlled trial
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9465857/
https://www.ncbi.nlm.nih.gov/pubmed/36096842
http://dx.doi.org/10.1186/s12905-022-01955-z
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