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Comprehensive comparison between azacytidine and decitabine treatment in an acute myeloid leukemia cell line

Azacytidine (AzaC) and decitabine (AzadC) are cytosine analogs that covalently trap DNA methyltransferases, which place the important epigenetic mark 5-methyl-2’-deoxycytidine by methylating 2’-deoxycytidine (dC) at the C5 position. AzaC and AzadC are used in the clinic as antimetabolites to treat m...

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Detalles Bibliográficos
Autores principales:	Aumer, Tina, Gremmelmaier, Constanze B., Runtsch, Leander S., Pforr, Johannes C., Yeşiltaç, G. Nur, Kaiser, Stefanie, Traube, Franziska R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9465881/ https://www.ncbi.nlm.nih.gov/pubmed/36089606 http://dx.doi.org/10.1186/s13148-022-01329-0

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