Modelling aggressive prostate cancers of young men in immune-competent mice, driven by isogenic Trp53 alterations and Pten loss

Understanding prostate cancer onset and progression in order to rationally treat this disease has been critically limited by a dire lack of relevant pre-clinical animal models. We have generated a set of genetically engineered mice that mimic human prostate cancer, initiated from the gland epithelia...

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Detalles Bibliográficos
Autores principales: Mejía-Hernández, Javier Octavio, Keam, Simon P., Saleh, Reem, Muntz, Fenella, Fox, Stephen B., Byrne, David, Kogan, Arielle, Pang, Lokman, Huynh, Jennifer, Litchfield, Cassandra, Caramia, Franco, Lozano, Guillermina, He, Hua, You, James M., Sandhu, Shahneen, Williams, Scott G., Haupt, Ygal, Haupt, Sue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9465983/
https://www.ncbi.nlm.nih.gov/pubmed/36075907
http://dx.doi.org/10.1038/s41419-022-05211-y

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