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The effect of antifungal resistance development on the virulence of Candida species

In recent years, the relevance of diseases associated with fungal pathogens increased worldwide. Members of the Candida genus are responsible for the greatest number of fungal bloodstream infections every year. Epidemiological data consistently indicate a modest shift toward non-albicans species, al...

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Autores principales: Bohner, Flora, Papp, Csaba, Gácser, Attila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9466593/
https://www.ncbi.nlm.nih.gov/pubmed/35325128
http://dx.doi.org/10.1093/femsyr/foac019
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author Bohner, Flora
Papp, Csaba
Gácser, Attila
author_facet Bohner, Flora
Papp, Csaba
Gácser, Attila
author_sort Bohner, Flora
collection PubMed
description In recent years, the relevance of diseases associated with fungal pathogens increased worldwide. Members of the Candida genus are responsible for the greatest number of fungal bloodstream infections every year. Epidemiological data consistently indicate a modest shift toward non-albicans species, albeit Candidaalbicans is still the most recognizable species within the genus. As a result, the number of clinically relevant pathogens has increased, and, despite their distinct pathogenicity features, the applicable antifungal agents remained the same. For bloodstream infections, only three classes of drugs are routinely used, namely polyenes, azoles and echinocandins. Antifungal resistance toward all three antifungal drug classes frequently occurs in clinical settings. Compared with the broad range of literature on virulence and antifungal resistance of Candida species separately, only a small portion of studies examined the effect of resistance on virulence. These studies found that resistance to polyenes and echinocandins concluded in significant decrease in the virulence in different Candida species. Meanwhile, in some cases, resistance to azole type antifungals resulted in increased virulence depending on the species and isolates. These findings underline the importance of studies aiming to dissect the connections of virulence and resistance in Candida species.
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spelling pubmed-94665932022-09-13 The effect of antifungal resistance development on the virulence of Candida species Bohner, Flora Papp, Csaba Gácser, Attila FEMS Yeast Res Minireview In recent years, the relevance of diseases associated with fungal pathogens increased worldwide. Members of the Candida genus are responsible for the greatest number of fungal bloodstream infections every year. Epidemiological data consistently indicate a modest shift toward non-albicans species, albeit Candidaalbicans is still the most recognizable species within the genus. As a result, the number of clinically relevant pathogens has increased, and, despite their distinct pathogenicity features, the applicable antifungal agents remained the same. For bloodstream infections, only three classes of drugs are routinely used, namely polyenes, azoles and echinocandins. Antifungal resistance toward all three antifungal drug classes frequently occurs in clinical settings. Compared with the broad range of literature on virulence and antifungal resistance of Candida species separately, only a small portion of studies examined the effect of resistance on virulence. These studies found that resistance to polyenes and echinocandins concluded in significant decrease in the virulence in different Candida species. Meanwhile, in some cases, resistance to azole type antifungals resulted in increased virulence depending on the species and isolates. These findings underline the importance of studies aiming to dissect the connections of virulence and resistance in Candida species. Oxford University Press 2022-03-23 /pmc/articles/PMC9466593/ /pubmed/35325128 http://dx.doi.org/10.1093/femsyr/foac019 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of FEMS. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Minireview
Bohner, Flora
Papp, Csaba
Gácser, Attila
The effect of antifungal resistance development on the virulence of Candida species
title The effect of antifungal resistance development on the virulence of Candida species
title_full The effect of antifungal resistance development on the virulence of Candida species
title_fullStr The effect of antifungal resistance development on the virulence of Candida species
title_full_unstemmed The effect of antifungal resistance development on the virulence of Candida species
title_short The effect of antifungal resistance development on the virulence of Candida species
title_sort effect of antifungal resistance development on the virulence of candida species
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9466593/
https://www.ncbi.nlm.nih.gov/pubmed/35325128
http://dx.doi.org/10.1093/femsyr/foac019
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