Vitamin D(3) and carbamazepine protect against Clostridioides difficile infection in mice by restoring macrophage lysosome acidification

Clostridioides difficile infection (CDI) is a common cause of nosocomial diarrhea. TcdB is a major C. difficile exotoxin that activates macrophages to promote inflammation and epithelial damage. Lysosome impairment is a known trigger for inflammation. Herein, we hypothesize that TcdB could impair ma...

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Detalles Bibliográficos
Autores principales: Chan, Hung, Li, Qing, Wang, Xiansong, Liu, Wing Yingzhi, Hu, Wei, Zeng, Judeng, Xie, Chuan, Kwong, Thomas Ngai Yeung, Ho, Idy Hiu Ting, Liu, Xiaodong, Chen, Huarong, Yu, Jun, Ko, Ho, Chan, Raphael Chiu Yeung, Ip, Margaret, Gin, Tony, Cheng, Alfred Sze Lok, Zhang, Lin, Chan, Matthew Tak Vai, Wong, Sunny Hei, Wu, William Ka Kei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9466624/
https://www.ncbi.nlm.nih.gov/pubmed/34989311
http://dx.doi.org/10.1080/15548627.2021.2016004

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