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Clinical presentation and in-hospital prognosis of lung cancer patients presenting with suspected and confirmed COVID-19

We sought to compare the clinical presentation and prognosis of patients with lung cancer and confirmed COVID-19 infection to those with negative RT-PCR SARS-CoV-2 results. We included patients with confirmed lung cancer and suspected COVID-19 who presented to the emergency department. The primary o...

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Autores principales: Peixoto, D., Callia, J.P.B., Bittencourt, M.S., Generoso, G., Anastácio, V.M., Alves-Jr., J.L., da Silva, T.L., Belizário, J.C., Araújo, B.L.M., Ho, W., Diz, M.D.P.E., Hoff, P.M., Abdala, E., Ibrahim, K.Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Associação Brasileira de Divulgação Científica 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9467285/
https://www.ncbi.nlm.nih.gov/pubmed/36102415
http://dx.doi.org/10.1590/1414-431X2022e12140
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author Peixoto, D.
Callia, J.P.B.
Bittencourt, M.S.
Generoso, G.
Anastácio, V.M.
Alves-Jr., J.L.
da Silva, T.L.
Belizário, J.C.
Araújo, B.L.M.
Ho, W.
Diz, M.D.P.E.
Hoff, P.M.
Abdala, E.
Ibrahim, K.Y.
author_facet Peixoto, D.
Callia, J.P.B.
Bittencourt, M.S.
Generoso, G.
Anastácio, V.M.
Alves-Jr., J.L.
da Silva, T.L.
Belizário, J.C.
Araújo, B.L.M.
Ho, W.
Diz, M.D.P.E.
Hoff, P.M.
Abdala, E.
Ibrahim, K.Y.
author_sort Peixoto, D.
collection PubMed
description We sought to compare the clinical presentation and prognosis of patients with lung cancer and confirmed COVID-19 infection to those with negative RT-PCR SARS-CoV-2 results. We included patients with confirmed lung cancer and suspected COVID-19 who presented to the emergency department. The primary outcome was in-hospital mortality and secondary outcomes included admission to intensive care unit (ICU) or mechanical ventilation. We analyzed the characteristics according to RT-PCR results and primary outcome. We constructed a logistic regression for each RT-PCR result group to find potential predictors of the primary outcome. Among 110 individuals with confirmed lung cancer (65±9 years, 51% male), 38 patients had positive RT-PCR and 72 patients had negative RT-PCR. There was no difference between groups for any clinical characteristic or comorbidities though individuals with confirmed COVID-19 had higher functionality in the ECOG scale. Leucocytes and lymphocytes were lower in individuals with positive tests. The primary outcome occurred in 58 (53%) individuals, 37 (34%) were admitted to the ICU, and 29 (26%) required mechanical ventilation. Although mortality was similar between the two groups, individuals with confirmed COVID-19 were significantly more likely to be admitted to the ICU or receive mechanical ventilation. Only lower lymphocytes and higher CRP were significantly associated with higher mortality. The clinical presentation of COVID-19 in lung cancer is not sufficient to identify higher or lower probability groups among symptomatic individuals, the overall mortality is high irrespective of RT-PCR results, and lymphopenia on admission was associated with the diagnosis and prognosis for COVID-19.
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spelling pubmed-94672852022-09-15 Clinical presentation and in-hospital prognosis of lung cancer patients presenting with suspected and confirmed COVID-19 Peixoto, D. Callia, J.P.B. Bittencourt, M.S. Generoso, G. Anastácio, V.M. Alves-Jr., J.L. da Silva, T.L. Belizário, J.C. Araújo, B.L.M. Ho, W. Diz, M.D.P.E. Hoff, P.M. Abdala, E. Ibrahim, K.Y. Braz J Med Biol Res Research Article We sought to compare the clinical presentation and prognosis of patients with lung cancer and confirmed COVID-19 infection to those with negative RT-PCR SARS-CoV-2 results. We included patients with confirmed lung cancer and suspected COVID-19 who presented to the emergency department. The primary outcome was in-hospital mortality and secondary outcomes included admission to intensive care unit (ICU) or mechanical ventilation. We analyzed the characteristics according to RT-PCR results and primary outcome. We constructed a logistic regression for each RT-PCR result group to find potential predictors of the primary outcome. Among 110 individuals with confirmed lung cancer (65±9 years, 51% male), 38 patients had positive RT-PCR and 72 patients had negative RT-PCR. There was no difference between groups for any clinical characteristic or comorbidities though individuals with confirmed COVID-19 had higher functionality in the ECOG scale. Leucocytes and lymphocytes were lower in individuals with positive tests. The primary outcome occurred in 58 (53%) individuals, 37 (34%) were admitted to the ICU, and 29 (26%) required mechanical ventilation. Although mortality was similar between the two groups, individuals with confirmed COVID-19 were significantly more likely to be admitted to the ICU or receive mechanical ventilation. Only lower lymphocytes and higher CRP were significantly associated with higher mortality. The clinical presentation of COVID-19 in lung cancer is not sufficient to identify higher or lower probability groups among symptomatic individuals, the overall mortality is high irrespective of RT-PCR results, and lymphopenia on admission was associated with the diagnosis and prognosis for COVID-19. Associação Brasileira de Divulgação Científica 2022-09-12 /pmc/articles/PMC9467285/ /pubmed/36102415 http://dx.doi.org/10.1590/1414-431X2022e12140 Text en https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Peixoto, D.
Callia, J.P.B.
Bittencourt, M.S.
Generoso, G.
Anastácio, V.M.
Alves-Jr., J.L.
da Silva, T.L.
Belizário, J.C.
Araújo, B.L.M.
Ho, W.
Diz, M.D.P.E.
Hoff, P.M.
Abdala, E.
Ibrahim, K.Y.
Clinical presentation and in-hospital prognosis of lung cancer patients presenting with suspected and confirmed COVID-19
title Clinical presentation and in-hospital prognosis of lung cancer patients presenting with suspected and confirmed COVID-19
title_full Clinical presentation and in-hospital prognosis of lung cancer patients presenting with suspected and confirmed COVID-19
title_fullStr Clinical presentation and in-hospital prognosis of lung cancer patients presenting with suspected and confirmed COVID-19
title_full_unstemmed Clinical presentation and in-hospital prognosis of lung cancer patients presenting with suspected and confirmed COVID-19
title_short Clinical presentation and in-hospital prognosis of lung cancer patients presenting with suspected and confirmed COVID-19
title_sort clinical presentation and in-hospital prognosis of lung cancer patients presenting with suspected and confirmed covid-19
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9467285/
https://www.ncbi.nlm.nih.gov/pubmed/36102415
http://dx.doi.org/10.1590/1414-431X2022e12140
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