Rhein promotes TRAIL-induced apoptosis in bladder cancer cells by up-regulating DR5 expression

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) combined with sensitizer is a potential method to reverse TRAIL-resistance in tumor cells. Rhein (RH) is a monomer extracted from Chinese herbs that has been reported to show anti-tumor effects in a variety of tumor cells, but the role...

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Autores principales: Ma, Liang, Wei, Hong-Ling, Wang, Ke-Jie, Meng, Xiang-Yu, Ni, Sai-Qi, Zhou, Cheng, Li, Yi, Yu, Rui, Ma, Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9467405/
https://www.ncbi.nlm.nih.gov/pubmed/35985770
http://dx.doi.org/10.18632/aging.204236
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author Ma, Liang
Wei, Hong-Ling
Wang, Ke-Jie
Meng, Xiang-Yu
Ni, Sai-Qi
Zhou, Cheng
Li, Yi
Yu, Rui
Ma, Qi
author_facet Ma, Liang
Wei, Hong-Ling
Wang, Ke-Jie
Meng, Xiang-Yu
Ni, Sai-Qi
Zhou, Cheng
Li, Yi
Yu, Rui
Ma, Qi
author_sort Ma, Liang
collection PubMed
description Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) combined with sensitizer is a potential method to reverse TRAIL-resistance in tumor cells. Rhein (RH) is a monomer extracted from Chinese herbs that has been reported to show anti-tumor effects in a variety of tumor cells, but the role of RH in TRAIL-induced anti-tumor effects in bladder cancer cells has not been reported. In this study, we found that the combined treatment of a non-toxic concentration of RH with TRAIL significantly inhibited the proliferation and induced apoptosis in both TRAIL sensitive and resistant bladder cancer cell lines. Furthermore, we found that RH promoted bladder cancer cell apoptosis by up-regulating DR5 expression. Our findings provide potential value in the clinical treatment of bladder cancer.
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spelling pubmed-94674052022-09-14 Rhein promotes TRAIL-induced apoptosis in bladder cancer cells by up-regulating DR5 expression Ma, Liang Wei, Hong-Ling Wang, Ke-Jie Meng, Xiang-Yu Ni, Sai-Qi Zhou, Cheng Li, Yi Yu, Rui Ma, Qi Aging (Albany NY) Research Paper Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) combined with sensitizer is a potential method to reverse TRAIL-resistance in tumor cells. Rhein (RH) is a monomer extracted from Chinese herbs that has been reported to show anti-tumor effects in a variety of tumor cells, but the role of RH in TRAIL-induced anti-tumor effects in bladder cancer cells has not been reported. In this study, we found that the combined treatment of a non-toxic concentration of RH with TRAIL significantly inhibited the proliferation and induced apoptosis in both TRAIL sensitive and resistant bladder cancer cell lines. Furthermore, we found that RH promoted bladder cancer cell apoptosis by up-regulating DR5 expression. Our findings provide potential value in the clinical treatment of bladder cancer. Impact Journals 2022-08-19 /pmc/articles/PMC9467405/ /pubmed/35985770 http://dx.doi.org/10.18632/aging.204236 Text en Copyright: © 2022 Ma et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Ma, Liang
Wei, Hong-Ling
Wang, Ke-Jie
Meng, Xiang-Yu
Ni, Sai-Qi
Zhou, Cheng
Li, Yi
Yu, Rui
Ma, Qi
Rhein promotes TRAIL-induced apoptosis in bladder cancer cells by up-regulating DR5 expression
title Rhein promotes TRAIL-induced apoptosis in bladder cancer cells by up-regulating DR5 expression
title_full Rhein promotes TRAIL-induced apoptosis in bladder cancer cells by up-regulating DR5 expression
title_fullStr Rhein promotes TRAIL-induced apoptosis in bladder cancer cells by up-regulating DR5 expression
title_full_unstemmed Rhein promotes TRAIL-induced apoptosis in bladder cancer cells by up-regulating DR5 expression
title_short Rhein promotes TRAIL-induced apoptosis in bladder cancer cells by up-regulating DR5 expression
title_sort rhein promotes trail-induced apoptosis in bladder cancer cells by up-regulating dr5 expression
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9467405/
https://www.ncbi.nlm.nih.gov/pubmed/35985770
http://dx.doi.org/10.18632/aging.204236
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