Complexes of Zinc(II)- and Copper(II) Perchlorates with Nicotinamide: Synthesis, Structure, Cytotoxicity

Interaction of zinc(II)- and copper(II) perchlorate hexahydrates with nicotinamide (Nia – nicotinamide, niacinamide, 3-pyridinecarboxamide, C(5)H(4)NС(O)NH(2)) has been studied. It has been demonstrated that complex compounds [Zn(Nia)(2)(H(2)O)(4)](ClO(4))(2) (1) and [Cu(Nia)(2)(H(2)O)(2)](ClO(4))(2) ⋅ 2H(2)O (2) are formed in aqueous media at the molar ratio M(ClO(4))(2) ⋅ 6H(2)O : Nia = 1 : 2. Both compounds are the ionic ones. Geometry of complex cation (1) may be represented as a distorted octahedron in which nicotinamide molecules are in the trans-position. The same position of ligands is found for planar complex cation (2). Cytotoxicity of the prepared compounds (MTT assay) has been determined with respect to dental pulp stem cells (DPSC) and breast cancer cell line MCF-7. Antiproliferative activity has been studied relative to 10 cancer cell lines, complex compound (1) being the most toxic for C6, Panc-1, U251 cell lines (survivability below 15%).