Identification of novel pyrrolopyrimidine and pyrrolopyridine derivatives as potent ENPP1 inhibitors

In an effort to discover novel scaffolds of non-nucleotide-derived Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) inhibitors to stimulate the Stimulator of Interferon Genes (STING) pathway, we designed and synthesised pyrrolopyrimidine and pyrrolopyridine derivatives and performed struct...

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Detalles Bibliográficos
Autores principales: Jeong, Hee Jin, Lee, Hye Lim, Kim, Sung Joon, Jeong, Jeong Hyun, Ji, Su Hyun, Kim, Han Byeol, Kang, Miso, Chung, Hwan Won, Park, Chan Sun, Choo, Hyunah, Yoon, Hyo Jae, Kim, Nam-Jung, Lee, Duck-Hyung, Lee, Sang Hee, Han, Seo-Jung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9467556/
https://www.ncbi.nlm.nih.gov/pubmed/36069240
http://dx.doi.org/10.1080/14756366.2022.2119566

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