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Biomaterials for Helicobacter pylori therapy: therapeutic potential and future perspectives

Helicobacter pylori (H. pylori) is the main cause of gastric adenocarcinoma. However, the traditional antibiotic treatment of H. pylori is limited due to increased antibiotic resistance and low efficacy; low drug delivery efficiency and difficulties in eradicating H. pylori that is present intracell...

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Autores principales: Lai, Yongkang, Wei, Wei, Du, Yiqi, Gao, Jie, Li, Zhaoshen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9467593/
https://www.ncbi.nlm.nih.gov/pubmed/36070564
http://dx.doi.org/10.1080/19490976.2022.2120747
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author Lai, Yongkang
Wei, Wei
Du, Yiqi
Gao, Jie
Li, Zhaoshen
author_facet Lai, Yongkang
Wei, Wei
Du, Yiqi
Gao, Jie
Li, Zhaoshen
author_sort Lai, Yongkang
collection PubMed
description Helicobacter pylori (H. pylori) is the main cause of gastric adenocarcinoma. However, the traditional antibiotic treatment of H. pylori is limited due to increased antibiotic resistance and low efficacy; low drug delivery efficiency and difficulties in eradicating H. pylori that is present intracellularly or in biofilms cause further setbacks. Biomaterials that can protect drugs against stomach acid, target lesions, control drug release, destroy biofilms, and exhibit unique antibacterial mechanisms and excellent biocompatibility have emerged as attractive tools for H. pylori eradication, particularly for drug-resistant strains. Herein, we review the virulence mechanisms, current drug treatments, and antibiotic resistance of H. pylori strains. Furthermore, recent advances in the development of biomaterials, including nanoparticles (such as lipid-based nanoparticles, polymeric nanoparticles, and inorganic nanoparticles), microspheres, and hydrogels, for effective and precise therapy of H. pylori and different types of therapeutic mechanisms, as well as future perspectives, have also been summarized.
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spelling pubmed-94675932022-09-13 Biomaterials for Helicobacter pylori therapy: therapeutic potential and future perspectives Lai, Yongkang Wei, Wei Du, Yiqi Gao, Jie Li, Zhaoshen Gut Microbes Review Helicobacter pylori (H. pylori) is the main cause of gastric adenocarcinoma. However, the traditional antibiotic treatment of H. pylori is limited due to increased antibiotic resistance and low efficacy; low drug delivery efficiency and difficulties in eradicating H. pylori that is present intracellularly or in biofilms cause further setbacks. Biomaterials that can protect drugs against stomach acid, target lesions, control drug release, destroy biofilms, and exhibit unique antibacterial mechanisms and excellent biocompatibility have emerged as attractive tools for H. pylori eradication, particularly for drug-resistant strains. Herein, we review the virulence mechanisms, current drug treatments, and antibiotic resistance of H. pylori strains. Furthermore, recent advances in the development of biomaterials, including nanoparticles (such as lipid-based nanoparticles, polymeric nanoparticles, and inorganic nanoparticles), microspheres, and hydrogels, for effective and precise therapy of H. pylori and different types of therapeutic mechanisms, as well as future perspectives, have also been summarized. Taylor & Francis 2022-09-07 /pmc/articles/PMC9467593/ /pubmed/36070564 http://dx.doi.org/10.1080/19490976.2022.2120747 Text en © 2022 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Lai, Yongkang
Wei, Wei
Du, Yiqi
Gao, Jie
Li, Zhaoshen
Biomaterials for Helicobacter pylori therapy: therapeutic potential and future perspectives
title Biomaterials for Helicobacter pylori therapy: therapeutic potential and future perspectives
title_full Biomaterials for Helicobacter pylori therapy: therapeutic potential and future perspectives
title_fullStr Biomaterials for Helicobacter pylori therapy: therapeutic potential and future perspectives
title_full_unstemmed Biomaterials for Helicobacter pylori therapy: therapeutic potential and future perspectives
title_short Biomaterials for Helicobacter pylori therapy: therapeutic potential and future perspectives
title_sort biomaterials for helicobacter pylori therapy: therapeutic potential and future perspectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9467593/
https://www.ncbi.nlm.nih.gov/pubmed/36070564
http://dx.doi.org/10.1080/19490976.2022.2120747
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