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Biomaterials for Helicobacter pylori therapy: therapeutic potential and future perspectives
Helicobacter pylori (H. pylori) is the main cause of gastric adenocarcinoma. However, the traditional antibiotic treatment of H. pylori is limited due to increased antibiotic resistance and low efficacy; low drug delivery efficiency and difficulties in eradicating H. pylori that is present intracell...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9467593/ https://www.ncbi.nlm.nih.gov/pubmed/36070564 http://dx.doi.org/10.1080/19490976.2022.2120747 |
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author | Lai, Yongkang Wei, Wei Du, Yiqi Gao, Jie Li, Zhaoshen |
author_facet | Lai, Yongkang Wei, Wei Du, Yiqi Gao, Jie Li, Zhaoshen |
author_sort | Lai, Yongkang |
collection | PubMed |
description | Helicobacter pylori (H. pylori) is the main cause of gastric adenocarcinoma. However, the traditional antibiotic treatment of H. pylori is limited due to increased antibiotic resistance and low efficacy; low drug delivery efficiency and difficulties in eradicating H. pylori that is present intracellularly or in biofilms cause further setbacks. Biomaterials that can protect drugs against stomach acid, target lesions, control drug release, destroy biofilms, and exhibit unique antibacterial mechanisms and excellent biocompatibility have emerged as attractive tools for H. pylori eradication, particularly for drug-resistant strains. Herein, we review the virulence mechanisms, current drug treatments, and antibiotic resistance of H. pylori strains. Furthermore, recent advances in the development of biomaterials, including nanoparticles (such as lipid-based nanoparticles, polymeric nanoparticles, and inorganic nanoparticles), microspheres, and hydrogels, for effective and precise therapy of H. pylori and different types of therapeutic mechanisms, as well as future perspectives, have also been summarized. |
format | Online Article Text |
id | pubmed-9467593 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-94675932022-09-13 Biomaterials for Helicobacter pylori therapy: therapeutic potential and future perspectives Lai, Yongkang Wei, Wei Du, Yiqi Gao, Jie Li, Zhaoshen Gut Microbes Review Helicobacter pylori (H. pylori) is the main cause of gastric adenocarcinoma. However, the traditional antibiotic treatment of H. pylori is limited due to increased antibiotic resistance and low efficacy; low drug delivery efficiency and difficulties in eradicating H. pylori that is present intracellularly or in biofilms cause further setbacks. Biomaterials that can protect drugs against stomach acid, target lesions, control drug release, destroy biofilms, and exhibit unique antibacterial mechanisms and excellent biocompatibility have emerged as attractive tools for H. pylori eradication, particularly for drug-resistant strains. Herein, we review the virulence mechanisms, current drug treatments, and antibiotic resistance of H. pylori strains. Furthermore, recent advances in the development of biomaterials, including nanoparticles (such as lipid-based nanoparticles, polymeric nanoparticles, and inorganic nanoparticles), microspheres, and hydrogels, for effective and precise therapy of H. pylori and different types of therapeutic mechanisms, as well as future perspectives, have also been summarized. Taylor & Francis 2022-09-07 /pmc/articles/PMC9467593/ /pubmed/36070564 http://dx.doi.org/10.1080/19490976.2022.2120747 Text en © 2022 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Lai, Yongkang Wei, Wei Du, Yiqi Gao, Jie Li, Zhaoshen Biomaterials for Helicobacter pylori therapy: therapeutic potential and future perspectives |
title | Biomaterials for Helicobacter pylori therapy: therapeutic potential and future perspectives |
title_full | Biomaterials for Helicobacter pylori therapy: therapeutic potential and future perspectives |
title_fullStr | Biomaterials for Helicobacter pylori therapy: therapeutic potential and future perspectives |
title_full_unstemmed | Biomaterials for Helicobacter pylori therapy: therapeutic potential and future perspectives |
title_short | Biomaterials for Helicobacter pylori therapy: therapeutic potential and future perspectives |
title_sort | biomaterials for helicobacter pylori therapy: therapeutic potential and future perspectives |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9467593/ https://www.ncbi.nlm.nih.gov/pubmed/36070564 http://dx.doi.org/10.1080/19490976.2022.2120747 |
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