Simultaneous affinity maturation and developability enhancement using natural liability-free CDRs

Affinity maturation is often a necessary step for the development of potent therapeutic molecules. Many different diversification strategies have been used for antibody affinity maturation, including error-prone PCR, chain shuffling, and targeted complementary-determining region (CDR) mutation. Alth...

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Detalles Bibliográficos
Autores principales: Teixeira, Andre A. R., D’Angelo, Sara, Erasmus, M. Frank, Leal-Lopes, Camila, Ferrara, Fortunato, Spector, Laura P., Naranjo, Leslie, Molina, Esteban, Max, Tamara, DeAguero, Ashley, Perea, Katherine, Stewart, Shaun, Buonpane, Rebecca A., Nastri, Horacio G., Bradbury, Andrew R. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9467613/
https://www.ncbi.nlm.nih.gov/pubmed/36068722
http://dx.doi.org/10.1080/19420862.2022.2115200

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