Selinexor in Advanced, Metastatic Dedifferentiated Liposarcoma: A Multinational, Randomized, Double-Blind, Placebo-Controlled Trial

Antitumor activity in preclinical models and a phase I study of patients with dedifferentiated liposarcoma (DD-LPS) was observed with selinexor. We evaluated the clinical benefit of selinexor in patients with previously treated DD-LPS whose sarcoma progressed on approved agents. METHODS: SEAL was a...

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Detalles Bibliográficos
Autores principales: Gounder, Mrinal M., Razak, Albiruni Abdul, Somaiah, Neeta, Chawla, Sant, Martin-Broto, Javier, Grignani, Giovanni, Schuetze, Scott M., Vincenzi, Bruno, Wagner, Andrew J., Chmielowski, Bartosz, Jones, Robin L., Riedel, Richard F., Stacchiotti, Silvia, Loggers, Elizabeth T., Ganjoo, Kristen N., Le Cesne, Axel, Italiano, Antoine, Garcia del Muro, Xavier, Burgess, Melissa, Piperno-Neumann, Sophie, Ryan, Christopher, Mulcahy, Mary F., Forscher, Charles, Penel, Nicolas, Okuno, Scott, Elias, Anthony, Hartner, Lee, Philip, Tony, Alcindor, Thierry, Kasper, Bernd, Reichardt, Peter, Lapeire, Lore, Blay, Jean-Yves, Chevreau, Christine, Valverde Morales, Claudia Maria, Schwartz, Gary K., Chen, James L., Deshpande, Hari, Davis, Elizabeth J., Nicholas, Garth, Gröschel, Stefan, Hatcher, Helen, Duffaud, Florence, Herráez, Antonio Casado, Beveridge, Roberto Diaz, Badalamenti, Giuseppe, Eriksson, Mikael, Meyer, Christian, von Mehren, Margaret, Van Tine, Brian A., Götze, Katharina, Mazzeo, Filomena, Yakobson, Alexander, Zick, Aviad, Lee, Alexander, Gonzalez, Anna Estival, Napolitano, Andrea, Dickson, Mark A., Michel, Dayana, Meng, Changting, Li, Lingling, Liu, Jianjun, Ben-Shahar, Osnat, Van Domelen, Dane R., Walker, Christopher J., Chang, Hua, Landesman, Yosef, Shah, Jatin J., Shacham, Sharon, Kauffman, Michael G., Attia, Steven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2022
Materias:
Original Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9467680/
https://www.ncbi.nlm.nih.gov/pubmed/35394800
http://dx.doi.org/10.1200/JCO.21.01829

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