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Natural Compounds for SIRT1-Mediated Oxidative Stress and Neuroinflammation in Stroke: A Potential Therapeutic Target in the Future

Stroke is a fatal cerebral vascular disease with a high mortality rate and substantial economic and social costs. ROS production and neuroinflammation have been implicated in both hemorrhagic and ischemic stroke and have the most critical effects on subsequent brain injury. SIRT1, a member of the si...

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Autores principales: Fang, Chaoyou, Xu, Houshi, Yuan, Ling, Zhu, Zhengyang, Wang, Xiaoyu, Liu, Yibo, Zhang, Anke, Shao, Anwen, Lou, Meiqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9467755/
https://www.ncbi.nlm.nih.gov/pubmed/36105479
http://dx.doi.org/10.1155/2022/1949718
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author Fang, Chaoyou
Xu, Houshi
Yuan, Ling
Zhu, Zhengyang
Wang, Xiaoyu
Liu, Yibo
Zhang, Anke
Shao, Anwen
Lou, Meiqing
author_facet Fang, Chaoyou
Xu, Houshi
Yuan, Ling
Zhu, Zhengyang
Wang, Xiaoyu
Liu, Yibo
Zhang, Anke
Shao, Anwen
Lou, Meiqing
author_sort Fang, Chaoyou
collection PubMed
description Stroke is a fatal cerebral vascular disease with a high mortality rate and substantial economic and social costs. ROS production and neuroinflammation have been implicated in both hemorrhagic and ischemic stroke and have the most critical effects on subsequent brain injury. SIRT1, a member of the sirtuin family, plays a crucial role in modulating a wide range of physiological processes, including apoptosis, DNA repair, inflammatory response, and oxidative stress. Targeting SIRT1 to reduce ROS and neuroinflammation might represent an emerging therapeutic target for stroke. Therefore, we conducted the present review to summarize the mechanisms of SIRT1-mediated oxidative stress and neuroinflammation in stroke. In addition, we provide a comprehensive introduction to the effect of compounds and natural drugs on SIRT1 signaling related to oxidative stress and neuroinflammation in stroke. We believe that our work will be helpful to further understand the critical role of the SIRT1 signaling pathway and will provide novel therapeutic potential for stroke treatment.
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spelling pubmed-94677552022-09-13 Natural Compounds for SIRT1-Mediated Oxidative Stress and Neuroinflammation in Stroke: A Potential Therapeutic Target in the Future Fang, Chaoyou Xu, Houshi Yuan, Ling Zhu, Zhengyang Wang, Xiaoyu Liu, Yibo Zhang, Anke Shao, Anwen Lou, Meiqing Oxid Med Cell Longev Review Article Stroke is a fatal cerebral vascular disease with a high mortality rate and substantial economic and social costs. ROS production and neuroinflammation have been implicated in both hemorrhagic and ischemic stroke and have the most critical effects on subsequent brain injury. SIRT1, a member of the sirtuin family, plays a crucial role in modulating a wide range of physiological processes, including apoptosis, DNA repair, inflammatory response, and oxidative stress. Targeting SIRT1 to reduce ROS and neuroinflammation might represent an emerging therapeutic target for stroke. Therefore, we conducted the present review to summarize the mechanisms of SIRT1-mediated oxidative stress and neuroinflammation in stroke. In addition, we provide a comprehensive introduction to the effect of compounds and natural drugs on SIRT1 signaling related to oxidative stress and neuroinflammation in stroke. We believe that our work will be helpful to further understand the critical role of the SIRT1 signaling pathway and will provide novel therapeutic potential for stroke treatment. Hindawi 2022-09-05 /pmc/articles/PMC9467755/ /pubmed/36105479 http://dx.doi.org/10.1155/2022/1949718 Text en Copyright © 2022 Chaoyou Fang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Fang, Chaoyou
Xu, Houshi
Yuan, Ling
Zhu, Zhengyang
Wang, Xiaoyu
Liu, Yibo
Zhang, Anke
Shao, Anwen
Lou, Meiqing
Natural Compounds for SIRT1-Mediated Oxidative Stress and Neuroinflammation in Stroke: A Potential Therapeutic Target in the Future
title Natural Compounds for SIRT1-Mediated Oxidative Stress and Neuroinflammation in Stroke: A Potential Therapeutic Target in the Future
title_full Natural Compounds for SIRT1-Mediated Oxidative Stress and Neuroinflammation in Stroke: A Potential Therapeutic Target in the Future
title_fullStr Natural Compounds for SIRT1-Mediated Oxidative Stress and Neuroinflammation in Stroke: A Potential Therapeutic Target in the Future
title_full_unstemmed Natural Compounds for SIRT1-Mediated Oxidative Stress and Neuroinflammation in Stroke: A Potential Therapeutic Target in the Future
title_short Natural Compounds for SIRT1-Mediated Oxidative Stress and Neuroinflammation in Stroke: A Potential Therapeutic Target in the Future
title_sort natural compounds for sirt1-mediated oxidative stress and neuroinflammation in stroke: a potential therapeutic target in the future
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9467755/
https://www.ncbi.nlm.nih.gov/pubmed/36105479
http://dx.doi.org/10.1155/2022/1949718
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