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Natural Compounds for SIRT1-Mediated Oxidative Stress and Neuroinflammation in Stroke: A Potential Therapeutic Target in the Future
Stroke is a fatal cerebral vascular disease with a high mortality rate and substantial economic and social costs. ROS production and neuroinflammation have been implicated in both hemorrhagic and ischemic stroke and have the most critical effects on subsequent brain injury. SIRT1, a member of the si...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9467755/ https://www.ncbi.nlm.nih.gov/pubmed/36105479 http://dx.doi.org/10.1155/2022/1949718 |
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author | Fang, Chaoyou Xu, Houshi Yuan, Ling Zhu, Zhengyang Wang, Xiaoyu Liu, Yibo Zhang, Anke Shao, Anwen Lou, Meiqing |
author_facet | Fang, Chaoyou Xu, Houshi Yuan, Ling Zhu, Zhengyang Wang, Xiaoyu Liu, Yibo Zhang, Anke Shao, Anwen Lou, Meiqing |
author_sort | Fang, Chaoyou |
collection | PubMed |
description | Stroke is a fatal cerebral vascular disease with a high mortality rate and substantial economic and social costs. ROS production and neuroinflammation have been implicated in both hemorrhagic and ischemic stroke and have the most critical effects on subsequent brain injury. SIRT1, a member of the sirtuin family, plays a crucial role in modulating a wide range of physiological processes, including apoptosis, DNA repair, inflammatory response, and oxidative stress. Targeting SIRT1 to reduce ROS and neuroinflammation might represent an emerging therapeutic target for stroke. Therefore, we conducted the present review to summarize the mechanisms of SIRT1-mediated oxidative stress and neuroinflammation in stroke. In addition, we provide a comprehensive introduction to the effect of compounds and natural drugs on SIRT1 signaling related to oxidative stress and neuroinflammation in stroke. We believe that our work will be helpful to further understand the critical role of the SIRT1 signaling pathway and will provide novel therapeutic potential for stroke treatment. |
format | Online Article Text |
id | pubmed-9467755 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-94677552022-09-13 Natural Compounds for SIRT1-Mediated Oxidative Stress and Neuroinflammation in Stroke: A Potential Therapeutic Target in the Future Fang, Chaoyou Xu, Houshi Yuan, Ling Zhu, Zhengyang Wang, Xiaoyu Liu, Yibo Zhang, Anke Shao, Anwen Lou, Meiqing Oxid Med Cell Longev Review Article Stroke is a fatal cerebral vascular disease with a high mortality rate and substantial economic and social costs. ROS production and neuroinflammation have been implicated in both hemorrhagic and ischemic stroke and have the most critical effects on subsequent brain injury. SIRT1, a member of the sirtuin family, plays a crucial role in modulating a wide range of physiological processes, including apoptosis, DNA repair, inflammatory response, and oxidative stress. Targeting SIRT1 to reduce ROS and neuroinflammation might represent an emerging therapeutic target for stroke. Therefore, we conducted the present review to summarize the mechanisms of SIRT1-mediated oxidative stress and neuroinflammation in stroke. In addition, we provide a comprehensive introduction to the effect of compounds and natural drugs on SIRT1 signaling related to oxidative stress and neuroinflammation in stroke. We believe that our work will be helpful to further understand the critical role of the SIRT1 signaling pathway and will provide novel therapeutic potential for stroke treatment. Hindawi 2022-09-05 /pmc/articles/PMC9467755/ /pubmed/36105479 http://dx.doi.org/10.1155/2022/1949718 Text en Copyright © 2022 Chaoyou Fang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Fang, Chaoyou Xu, Houshi Yuan, Ling Zhu, Zhengyang Wang, Xiaoyu Liu, Yibo Zhang, Anke Shao, Anwen Lou, Meiqing Natural Compounds for SIRT1-Mediated Oxidative Stress and Neuroinflammation in Stroke: A Potential Therapeutic Target in the Future |
title | Natural Compounds for SIRT1-Mediated Oxidative Stress and Neuroinflammation in Stroke: A Potential Therapeutic Target in the Future |
title_full | Natural Compounds for SIRT1-Mediated Oxidative Stress and Neuroinflammation in Stroke: A Potential Therapeutic Target in the Future |
title_fullStr | Natural Compounds for SIRT1-Mediated Oxidative Stress and Neuroinflammation in Stroke: A Potential Therapeutic Target in the Future |
title_full_unstemmed | Natural Compounds for SIRT1-Mediated Oxidative Stress and Neuroinflammation in Stroke: A Potential Therapeutic Target in the Future |
title_short | Natural Compounds for SIRT1-Mediated Oxidative Stress and Neuroinflammation in Stroke: A Potential Therapeutic Target in the Future |
title_sort | natural compounds for sirt1-mediated oxidative stress and neuroinflammation in stroke: a potential therapeutic target in the future |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9467755/ https://www.ncbi.nlm.nih.gov/pubmed/36105479 http://dx.doi.org/10.1155/2022/1949718 |
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