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Speech cortical activation and connectivity in typically developing children and those with listening difficulties

Listening difficulties (LiD) in people who have normal audiometry are a widespread but poorly understood form of hearing impairment. Recent research suggests that childhood LiD are cognitive rather than auditory in origin. We examined decoding of sentences using a novel combination of behavioral tes...

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Autores principales: Stewart, Hannah J., Cash, Erin K., Hunter, Lisa L., Maloney, Thomas, Vannest, Jennifer, Moore, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9467868/
https://www.ncbi.nlm.nih.gov/pubmed/36087559
http://dx.doi.org/10.1016/j.nicl.2022.103172
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author Stewart, Hannah J.
Cash, Erin K.
Hunter, Lisa L.
Maloney, Thomas
Vannest, Jennifer
Moore, David R.
author_facet Stewart, Hannah J.
Cash, Erin K.
Hunter, Lisa L.
Maloney, Thomas
Vannest, Jennifer
Moore, David R.
author_sort Stewart, Hannah J.
collection PubMed
description Listening difficulties (LiD) in people who have normal audiometry are a widespread but poorly understood form of hearing impairment. Recent research suggests that childhood LiD are cognitive rather than auditory in origin. We examined decoding of sentences using a novel combination of behavioral testing and fMRI with 43 typically developing children and 42 age matched (6–13 years old) children with LiD, categorized by caregiver report (ECLiPS). Both groups had clinically normal hearing. For sentence listening tasks, we found no group differences in fMRI brain cortical activation by increasingly complex speech stimuli that progressed in emphasis from phonology to intelligibility to semantics. Using resting state fMRI, we examined the temporal connectivity of cortical auditory and related speech perception networks. We found significant group differences only in cortical connections engaged when processing more complex speech stimuli. The strength of the affected connections was related to the children’s performance on tests of dichotic listening, speech-in-noise, attention, memory and verbal vocabulary. Together, these results support the novel hypothesis that childhood LiD reflects difficulties in language rather than in auditory or phonological processing.
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spelling pubmed-94678682022-09-14 Speech cortical activation and connectivity in typically developing children and those with listening difficulties Stewart, Hannah J. Cash, Erin K. Hunter, Lisa L. Maloney, Thomas Vannest, Jennifer Moore, David R. Neuroimage Clin Regular Article Listening difficulties (LiD) in people who have normal audiometry are a widespread but poorly understood form of hearing impairment. Recent research suggests that childhood LiD are cognitive rather than auditory in origin. We examined decoding of sentences using a novel combination of behavioral testing and fMRI with 43 typically developing children and 42 age matched (6–13 years old) children with LiD, categorized by caregiver report (ECLiPS). Both groups had clinically normal hearing. For sentence listening tasks, we found no group differences in fMRI brain cortical activation by increasingly complex speech stimuli that progressed in emphasis from phonology to intelligibility to semantics. Using resting state fMRI, we examined the temporal connectivity of cortical auditory and related speech perception networks. We found significant group differences only in cortical connections engaged when processing more complex speech stimuli. The strength of the affected connections was related to the children’s performance on tests of dichotic listening, speech-in-noise, attention, memory and verbal vocabulary. Together, these results support the novel hypothesis that childhood LiD reflects difficulties in language rather than in auditory or phonological processing. Elsevier 2022-08-28 /pmc/articles/PMC9467868/ /pubmed/36087559 http://dx.doi.org/10.1016/j.nicl.2022.103172 Text en © 2022 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Regular Article
Stewart, Hannah J.
Cash, Erin K.
Hunter, Lisa L.
Maloney, Thomas
Vannest, Jennifer
Moore, David R.
Speech cortical activation and connectivity in typically developing children and those with listening difficulties
title Speech cortical activation and connectivity in typically developing children and those with listening difficulties
title_full Speech cortical activation and connectivity in typically developing children and those with listening difficulties
title_fullStr Speech cortical activation and connectivity in typically developing children and those with listening difficulties
title_full_unstemmed Speech cortical activation and connectivity in typically developing children and those with listening difficulties
title_short Speech cortical activation and connectivity in typically developing children and those with listening difficulties
title_sort speech cortical activation and connectivity in typically developing children and those with listening difficulties
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9467868/
https://www.ncbi.nlm.nih.gov/pubmed/36087559
http://dx.doi.org/10.1016/j.nicl.2022.103172
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