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Managing food allergy: GA(2)LEN guideline 2022
Food allergy affects approximately 2–4% of children and adults. This guideline provides recommendations for managing food allergy from the Global Allergy and Asthma European Network (GA(2)LEN). A multidisciplinary international Task Force developed the guideline using the Appraisal of Guidelines for...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
World Allergy Organization
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9467869/ https://www.ncbi.nlm.nih.gov/pubmed/36119657 http://dx.doi.org/10.1016/j.waojou.2022.100687 |
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author | Muraro, Antonella de Silva, Debra Halken, Susanne Worm, Margitta Khaleva, Ekaterina Arasi, Stefania Dunn-Galvin, Audrey Nwaru, Bright I. De Jong, Nicolette W. Rodríguez Del Río, Pablo Turner, Paul J. Smith, Pete Begin, Philippe Angier, Elizabeth Arshad, Hasan Ballmer-Weber, Barbara Beyer, Kirsten Bindslev-Jensen, Carsten Cianferoni, Antonella Demoulin, Céline Deschildre, Antoine Ebisawa, Motohiro Fernandez-Rivas, Maria Montserrat Fiocchi, Alessandro Flokstra-de Blok, Bertine Gerdts, Jennifer Gradman, Josefine Grimshaw, Kate Jones, Carla Lau, Susanne Loh, Richard Alvaro Lozano, Montserrat Makela, Mika Marchisotto, Mary Jane Meyer, Rosan Mills, Clare Nilsson, Caroline Nowak-Wegrzyn, Anna Nurmatov, Ulugbek Pajno, Giovanni Podestà, Marcia Poulsen, Lars K. Sampson, Hugh A. Sanchez, Angel Schnadt, Sabine Szajewska, Hania Van Ree, Ronald Venter, Carina Vlieg-Boerstra, Berber Warner, Amena Wong, Gary Wood, Robert Zuberbier, Torsten Roberts, Graham |
author_facet | Muraro, Antonella de Silva, Debra Halken, Susanne Worm, Margitta Khaleva, Ekaterina Arasi, Stefania Dunn-Galvin, Audrey Nwaru, Bright I. De Jong, Nicolette W. Rodríguez Del Río, Pablo Turner, Paul J. Smith, Pete Begin, Philippe Angier, Elizabeth Arshad, Hasan Ballmer-Weber, Barbara Beyer, Kirsten Bindslev-Jensen, Carsten Cianferoni, Antonella Demoulin, Céline Deschildre, Antoine Ebisawa, Motohiro Fernandez-Rivas, Maria Montserrat Fiocchi, Alessandro Flokstra-de Blok, Bertine Gerdts, Jennifer Gradman, Josefine Grimshaw, Kate Jones, Carla Lau, Susanne Loh, Richard Alvaro Lozano, Montserrat Makela, Mika Marchisotto, Mary Jane Meyer, Rosan Mills, Clare Nilsson, Caroline Nowak-Wegrzyn, Anna Nurmatov, Ulugbek Pajno, Giovanni Podestà, Marcia Poulsen, Lars K. Sampson, Hugh A. Sanchez, Angel Schnadt, Sabine Szajewska, Hania Van Ree, Ronald Venter, Carina Vlieg-Boerstra, Berber Warner, Amena Wong, Gary Wood, Robert Zuberbier, Torsten Roberts, Graham |
author_sort | Muraro, Antonella |
collection | PubMed |
description | Food allergy affects approximately 2–4% of children and adults. This guideline provides recommendations for managing food allergy from the Global Allergy and Asthma European Network (GA(2)LEN). A multidisciplinary international Task Force developed the guideline using the Appraisal of Guidelines for Research and Evaluation (AGREE) II framework and the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach. We reviewed the latest available evidence as of April 2021 (161 studies) and created recommendations by balancing benefits, harms, feasibility, and patient and clinician experiences. We suggest that people diagnosed with food allergy avoid triggering allergens (low certainty evidence). We suggest that infants with cow's milk allergy who need a breastmilk alternative use either hypoallergenic extensively hydrolyzed cow's milk formula or an amino acid-based formula (moderate certainty). For selected children with peanut allergy, we recommend oral immunotherapy (high certainty), though epicutaneous immunotherapy might be considered depending on individual preferences and availability (moderate certainty). We suggest considering oral immunotherapy for children with persistent severe hen's egg or cow's milk allergy (moderate certainty). There are significant gaps in evidence about safety and effectiveness of the various strategies. Research is needed to determine the best approaches to education, how to predict the risk of severe reactions, whether immunotherapy is cost-effective and whether biological therapies are effective alone or combined with allergen immunotherapy. |
format | Online Article Text |
id | pubmed-9467869 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | World Allergy Organization |
record_format | MEDLINE/PubMed |
spelling | pubmed-94678692022-09-16 Managing food allergy: GA(2)LEN guideline 2022 Muraro, Antonella de Silva, Debra Halken, Susanne Worm, Margitta Khaleva, Ekaterina Arasi, Stefania Dunn-Galvin, Audrey Nwaru, Bright I. De Jong, Nicolette W. Rodríguez Del Río, Pablo Turner, Paul J. Smith, Pete Begin, Philippe Angier, Elizabeth Arshad, Hasan Ballmer-Weber, Barbara Beyer, Kirsten Bindslev-Jensen, Carsten Cianferoni, Antonella Demoulin, Céline Deschildre, Antoine Ebisawa, Motohiro Fernandez-Rivas, Maria Montserrat Fiocchi, Alessandro Flokstra-de Blok, Bertine Gerdts, Jennifer Gradman, Josefine Grimshaw, Kate Jones, Carla Lau, Susanne Loh, Richard Alvaro Lozano, Montserrat Makela, Mika Marchisotto, Mary Jane Meyer, Rosan Mills, Clare Nilsson, Caroline Nowak-Wegrzyn, Anna Nurmatov, Ulugbek Pajno, Giovanni Podestà, Marcia Poulsen, Lars K. Sampson, Hugh A. Sanchez, Angel Schnadt, Sabine Szajewska, Hania Van Ree, Ronald Venter, Carina Vlieg-Boerstra, Berber Warner, Amena Wong, Gary Wood, Robert Zuberbier, Torsten Roberts, Graham World Allergy Organ J Review Food allergy affects approximately 2–4% of children and adults. This guideline provides recommendations for managing food allergy from the Global Allergy and Asthma European Network (GA(2)LEN). A multidisciplinary international Task Force developed the guideline using the Appraisal of Guidelines for Research and Evaluation (AGREE) II framework and the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach. We reviewed the latest available evidence as of April 2021 (161 studies) and created recommendations by balancing benefits, harms, feasibility, and patient and clinician experiences. We suggest that people diagnosed with food allergy avoid triggering allergens (low certainty evidence). We suggest that infants with cow's milk allergy who need a breastmilk alternative use either hypoallergenic extensively hydrolyzed cow's milk formula or an amino acid-based formula (moderate certainty). For selected children with peanut allergy, we recommend oral immunotherapy (high certainty), though epicutaneous immunotherapy might be considered depending on individual preferences and availability (moderate certainty). We suggest considering oral immunotherapy for children with persistent severe hen's egg or cow's milk allergy (moderate certainty). There are significant gaps in evidence about safety and effectiveness of the various strategies. Research is needed to determine the best approaches to education, how to predict the risk of severe reactions, whether immunotherapy is cost-effective and whether biological therapies are effective alone or combined with allergen immunotherapy. World Allergy Organization 2022-09-07 /pmc/articles/PMC9467869/ /pubmed/36119657 http://dx.doi.org/10.1016/j.waojou.2022.100687 Text en © 2022 Published by Elsevier Inc. on behalf of World Allergy Organization. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Muraro, Antonella de Silva, Debra Halken, Susanne Worm, Margitta Khaleva, Ekaterina Arasi, Stefania Dunn-Galvin, Audrey Nwaru, Bright I. De Jong, Nicolette W. Rodríguez Del Río, Pablo Turner, Paul J. Smith, Pete Begin, Philippe Angier, Elizabeth Arshad, Hasan Ballmer-Weber, Barbara Beyer, Kirsten Bindslev-Jensen, Carsten Cianferoni, Antonella Demoulin, Céline Deschildre, Antoine Ebisawa, Motohiro Fernandez-Rivas, Maria Montserrat Fiocchi, Alessandro Flokstra-de Blok, Bertine Gerdts, Jennifer Gradman, Josefine Grimshaw, Kate Jones, Carla Lau, Susanne Loh, Richard Alvaro Lozano, Montserrat Makela, Mika Marchisotto, Mary Jane Meyer, Rosan Mills, Clare Nilsson, Caroline Nowak-Wegrzyn, Anna Nurmatov, Ulugbek Pajno, Giovanni Podestà, Marcia Poulsen, Lars K. Sampson, Hugh A. Sanchez, Angel Schnadt, Sabine Szajewska, Hania Van Ree, Ronald Venter, Carina Vlieg-Boerstra, Berber Warner, Amena Wong, Gary Wood, Robert Zuberbier, Torsten Roberts, Graham Managing food allergy: GA(2)LEN guideline 2022 |
title | Managing food allergy: GA(2)LEN guideline 2022 |
title_full | Managing food allergy: GA(2)LEN guideline 2022 |
title_fullStr | Managing food allergy: GA(2)LEN guideline 2022 |
title_full_unstemmed | Managing food allergy: GA(2)LEN guideline 2022 |
title_short | Managing food allergy: GA(2)LEN guideline 2022 |
title_sort | managing food allergy: ga(2)len guideline 2022 |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9467869/ https://www.ncbi.nlm.nih.gov/pubmed/36119657 http://dx.doi.org/10.1016/j.waojou.2022.100687 |
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