Autoinhibition of the GEF activity of cytoskeletal regulatory protein Trio is disrupted in neurodevelopmental disorder-related genetic variants

TRIO encodes a cytoskeletal regulatory protein with three catalytic domains—two guanine exchange factor (GEF) domains, GEF1 and GEF2, and a kinase domain—as well as several accessory domains that have not been extensively studied. Function-damaging variants in the TRIO gene are known to be enriched...

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Detalles Bibliográficos
Autores principales: Bircher, Josie E., Corcoran, Ellen E., Lam, TuKiet T., Trnka, Michael J., Koleske, Anthony J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9467883/
https://www.ncbi.nlm.nih.gov/pubmed/35963430
http://dx.doi.org/10.1016/j.jbc.2022.102361

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