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Effect of piperine on the mitigation of obesity associated with gut microbiota alteration

An obese mouse model induced by high-fat diet (HFD) feeding was used to reveal the role of piperine in modulating gut microbiota (GM). Piperine was administrated at 20 and 40 mg/kg body weight every day. As a result, piperine at 40 mg/kg significantly decreased body weight, liver weight, perirenal f...

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Autores principales: He, Jianlin, Le, Qingqing, Wei, Yufeng, Yang, Longhe, Cai, Bing, Liu, Yuansen, Hong, Bihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9467908/
https://www.ncbi.nlm.nih.gov/pubmed/36110383
http://dx.doi.org/10.1016/j.crfs.2022.08.018
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author He, Jianlin
Le, Qingqing
Wei, Yufeng
Yang, Longhe
Cai, Bing
Liu, Yuansen
Hong, Bihong
author_facet He, Jianlin
Le, Qingqing
Wei, Yufeng
Yang, Longhe
Cai, Bing
Liu, Yuansen
Hong, Bihong
author_sort He, Jianlin
collection PubMed
description An obese mouse model induced by high-fat diet (HFD) feeding was used to reveal the role of piperine in modulating gut microbiota (GM). Piperine was administrated at 20 and 40 mg/kg body weight every day. As a result, piperine at 40 mg/kg significantly decreased body weight, liver weight, perirenal fat weight, and lowered serum triglycerides, total cholesterol, low-density lipoprotein cholesterol, and glucose levels in HFD-fed mice. Additionally, piperine significantly attenuated fatty liver and modulated hepatic mRNA expressions of SREBP-1c, SREBP2, and HMGCR. In perirenal fat, FAS, C/EBPα, MCP1, and IL-6 expressions were significantly downregulated by piperine. 16S rRNA sequencing revealed that piperine elevated GM diversity. The relative abundance of Muribaculaceae and Ruminococcaceae were significantly elevated, while Dubosiella and Enterorhabdus genera were suppressed by piperine. The Pearson correlation analysis showed that the altered phylotypes were highly correlated with obesity phenotypes. These findings suggest that piperine modulates energy homeostasis and inflammation to alleviate obesity associated with GM regulation.
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spelling pubmed-94679082022-09-14 Effect of piperine on the mitigation of obesity associated with gut microbiota alteration He, Jianlin Le, Qingqing Wei, Yufeng Yang, Longhe Cai, Bing Liu, Yuansen Hong, Bihong Curr Res Food Sci Research Paper An obese mouse model induced by high-fat diet (HFD) feeding was used to reveal the role of piperine in modulating gut microbiota (GM). Piperine was administrated at 20 and 40 mg/kg body weight every day. As a result, piperine at 40 mg/kg significantly decreased body weight, liver weight, perirenal fat weight, and lowered serum triglycerides, total cholesterol, low-density lipoprotein cholesterol, and glucose levels in HFD-fed mice. Additionally, piperine significantly attenuated fatty liver and modulated hepatic mRNA expressions of SREBP-1c, SREBP2, and HMGCR. In perirenal fat, FAS, C/EBPα, MCP1, and IL-6 expressions were significantly downregulated by piperine. 16S rRNA sequencing revealed that piperine elevated GM diversity. The relative abundance of Muribaculaceae and Ruminococcaceae were significantly elevated, while Dubosiella and Enterorhabdus genera were suppressed by piperine. The Pearson correlation analysis showed that the altered phylotypes were highly correlated with obesity phenotypes. These findings suggest that piperine modulates energy homeostasis and inflammation to alleviate obesity associated with GM regulation. Elsevier 2022-09-02 /pmc/articles/PMC9467908/ /pubmed/36110383 http://dx.doi.org/10.1016/j.crfs.2022.08.018 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Paper
He, Jianlin
Le, Qingqing
Wei, Yufeng
Yang, Longhe
Cai, Bing
Liu, Yuansen
Hong, Bihong
Effect of piperine on the mitigation of obesity associated with gut microbiota alteration
title Effect of piperine on the mitigation of obesity associated with gut microbiota alteration
title_full Effect of piperine on the mitigation of obesity associated with gut microbiota alteration
title_fullStr Effect of piperine on the mitigation of obesity associated with gut microbiota alteration
title_full_unstemmed Effect of piperine on the mitigation of obesity associated with gut microbiota alteration
title_short Effect of piperine on the mitigation of obesity associated with gut microbiota alteration
title_sort effect of piperine on the mitigation of obesity associated with gut microbiota alteration
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9467908/
https://www.ncbi.nlm.nih.gov/pubmed/36110383
http://dx.doi.org/10.1016/j.crfs.2022.08.018
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