Loss of LAMP5 interneurons drives neuronal network dysfunction in Alzheimer’s disease

In Alzheimer’s disease (AD), where amyloid-β (Aβ) and tau deposits in the brain, hyperexcitation of neuronal networks is an underlying disease mechanism, but its cause remains unclear. Here, we used the Collaborative Cross (CC) forward genetics mouse platform to identify modifier genes of neuronal h...

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Detalles Bibliográficos
Autores principales: Deng, Yuanyuan, Bi, Mian, Delerue, Fabien, Forrest, Shelley L., Chan, Gabriella, van der Hoven, Julia, van Hummel, Annika, Feiten, Astrid F., Lee, Seojin, Martinez-Valbuena, Ivan, Karl, Tim, Kovacs, Gabor G., Morahan, Grant, Ke, Yazi D., Ittner, Lars M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9467963/
https://www.ncbi.nlm.nih.gov/pubmed/35780436
http://dx.doi.org/10.1007/s00401-022-02457-w

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