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Elucidation of divergent desaturation pathways in the formation of vinyl isonitrile and isocyanoacrylate

Two different types of desaturations are employed by iron- and 2-oxoglutarate-dependent (Fe/2OG) enzymes to construct vinyl isonitrile and isocyanoacrylate moieties found in isonitrile-containing natural products. A substrate-bound protein structure reveals a plausible strategy to affect desaturatio...

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Detalles Bibliográficos
Autores principales:	Kim, Wantae, Chen, Tzu-Yu, Cha, Lide, Zhou, Grace, Xing, Kristi, Canty, Nicholas Koenig, Zhang, Yan, Chang, Wei-chen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9467999/ https://www.ncbi.nlm.nih.gov/pubmed/36097268 http://dx.doi.org/10.1038/s41467-022-32870-4

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