Potency of botulinum toxin drugs: test systems and labelling

Cell-based assays are a novel method to determine potency of botulinum toxin drugs. Manufacturers are working on their acquisition, development and implementation to reduce animal consumption during the manufacturing process. Potency labelling of botulinum toxin drugs differes principally between Ip...

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Detalles Bibliográficos
Autores principales: Dressler, Dirk, Johnson, Eric A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2022
Materias:
Neurology and Preclinical Neurological Studies - Short communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468031/
https://www.ncbi.nlm.nih.gov/pubmed/36040625
http://dx.doi.org/10.1007/s00702-022-02535-z
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author Dressler, Dirk
Johnson, Eric A
author_facet Dressler, Dirk
Johnson, Eric A
author_sort Dressler, Dirk
collection PubMed
description Cell-based assays are a novel method to determine potency of botulinum toxin drugs. Manufacturers are working on their acquisition, development and implementation to reduce animal consumption during the manufacturing process. Potency labelling of botulinum toxin drugs differes principally between Ipsen and the other manufacturers. Reference to a uniform international standard would avoid this potentially dangerous situation. However, this has not been demanded by the registration authorities and has not been persued by the manufacturers for decades.
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spelling pubmed-94680312022-09-14 Potency of botulinum toxin drugs: test systems and labelling Dressler, Dirk Johnson, Eric A J Neural Transm (Vienna) Neurology and Preclinical Neurological Studies - Short communication Cell-based assays are a novel method to determine potency of botulinum toxin drugs. Manufacturers are working on their acquisition, development and implementation to reduce animal consumption during the manufacturing process. Potency labelling of botulinum toxin drugs differes principally between Ipsen and the other manufacturers. Reference to a uniform international standard would avoid this potentially dangerous situation. However, this has not been demanded by the registration authorities and has not been persued by the manufacturers for decades. Springer Vienna 2022-08-30 2022 /pmc/articles/PMC9468031/ /pubmed/36040625 http://dx.doi.org/10.1007/s00702-022-02535-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Neurology and Preclinical Neurological Studies - Short communication
Dressler, Dirk
Johnson, Eric A
Potency of botulinum toxin drugs: test systems and labelling
title Potency of botulinum toxin drugs: test systems and labelling
title_full Potency of botulinum toxin drugs: test systems and labelling
title_fullStr Potency of botulinum toxin drugs: test systems and labelling
title_full_unstemmed Potency of botulinum toxin drugs: test systems and labelling
title_short Potency of botulinum toxin drugs: test systems and labelling
title_sort potency of botulinum toxin drugs: test systems and labelling
topic Neurology and Preclinical Neurological Studies - Short communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468031/
https://www.ncbi.nlm.nih.gov/pubmed/36040625
http://dx.doi.org/10.1007/s00702-022-02535-z
work_keys_str_mv AT dresslerdirk potencyofbotulinumtoxindrugstestsystemsandlabelling
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