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Single-nucleus chromatin accessibility profiling highlights distinct astrocyte signatures in progressive supranuclear palsy and corticobasal degeneration

Tauopathies such as progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) exhibit characteristic neuronal and glial inclusions of hyperphosphorylated Tau (pTau). Although the astrocytic pTau phenotype upon neuropathological examination is the most guiding feature in distinguishing...

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Detalles Bibliográficos
Autores principales:	Briel, Nils, Ruf, Viktoria C., Pratsch, Katrin, Roeber, Sigrun, Widmann, Jeannine, Mielke, Janina, Dorostkar, Mario M., Windl, Otto, Arzberger, Thomas, Herms, Jochen, Struebing, Felix L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2022
Materias:	Original Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468099/ https://www.ncbi.nlm.nih.gov/pubmed/35976433 http://dx.doi.org/10.1007/s00401-022-02483-8

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