Cargando…

Transmission of cervid prions to humanized mice demonstrates the zoonotic potential of CWD

Prions cause infectious and fatal neurodegenerative diseases in mammals. Chronic wasting disease (CWD), a prion disease of cervids, spreads efficiently among wild and farmed animals. Potential transmission to humans of CWD is a growing concern due to its increasing prevalence. Here, we provide evide...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hannaoui, Samia, Zemlyankina, Irina, Chang, Sheng Chun, Arifin, Maria Immaculata, Béringue, Vincent, McKenzie, Debbie, Schatzl, Hermann M., Gilch, Sabine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2022
Materias:	Original Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468132/ https://www.ncbi.nlm.nih.gov/pubmed/35996016 http://dx.doi.org/10.1007/s00401-022-02482-9

Ejemplares similares

Cervid Prion Protein Polymorphisms: Role in Chronic Wasting Disease Pathogenesis
por: Arifin, Maria Immaculata, et al.
Publicado: (2021)

Heterozygosity for cervid S138N polymorphism results in subclinical CWD in gene-targeted mice and progressive inhibition of prion conversion
por: Arifin, Maria I., et al.
Publicado: (2023)

New and distinct chronic wasting disease strains associated with cervid polymorphism at codon 116 of the Prnp gene
por: Hannaoui, Samia, et al.
Publicado: (2021)

Genetic modulation of CWD prion propagation in cervid PrP Drosophila
por: Thackray, Alana M., et al.
Publicado: (2023)

Destabilizing polymorphism in cervid prion protein hydrophobic core determines prion conformation and conversion efficiency
por: Hannaoui, Samia, et al.
Publicado: (2017)

Chronic wasting disease: Emerging prions and their potential risk
por: Hannaoui, Samia, et al.
Publicado: (2017)

Shedding and stability of CWD prion seeding activity in cervid feces
por: Tennant, Joanne M., et al.
Publicado: (2020)

Cellulose ether treatment in vivo generates chronic wasting disease prions with reduced protease resistance and delayed disease progression
por: Hannaoui, Samia, et al.
Publicado: (2019)

Chronic wasting disease (CWD) in cervids
por: Ricci, Antonia, et al.
Publicado: (2017)

Soil humic acids degrade CWD prions and reduce infectivity
por: Kuznetsova, Alsu, et al.
Publicado: (2018)

Propagation of PrP(Sc) in mice reveals impact of aggregate composition on prion disease pathogenesis
por: Chang, Sheng Chun, et al.
Publicado: (2023)

Oral administration of repurposed drug targeting Cyp46A1 increases survival times of prion infected mice
por: Ali, Tahir, et al.
Publicado: (2021)

Use of different RT-QuIC substrates for detecting CWD prions in the brain of Norwegian cervids
por: Bistaffa, Edoardo, et al.
Publicado: (2019)

Long-Term Incubation PrP(CWD) with Soils Affects Prion Recovery but Not Infectivity
por: Kuznetsova, Alsu, et al.
Publicado: (2020)

Chronic wasting disease: a cervid prion infection looming to spillover
por: Otero, Alicia, et al.
Publicado: (2021)

Loss of small GTPase Rab7 activation in prion infection negatively affects a feedback loop regulating neuronal cholesterol metabolism
por: Cherry, Pearl, et al.
Publicado: (2023)

Emergence of CWD strains
por: Otero, Alicia, et al.
Publicado: (2022)

Prion protein polymorphisms associated with reduced CWD susceptibility limit peripheral PrP(CWD) deposition in orally infected white-tailed deer
por: Otero, Alicia, et al.
Publicado: (2019)

Detection of CWD in cervids by RT-QuIC assay of third eyelids
por: Cooper, Sarah K., et al.
Publicado: (2019)

Chronic Wasting Disease (CWD) in Cervids and the Consequences of a Mutable Protein Conformation
por: Silva, Christopher J.
Publicado: (2022)

Cholesterol Balance in Prion Diseases and Alzheimer’s Disease
por: Hannaoui, Samia, et al.
Publicado: (2014)

White-tailed deer S96 prion protein does not support stable in vitro propagation of most common CWD strains
por: Otero, Alicia, et al.
Publicado: (2021)

Chronic wasting disease (CWD) prion strains evolve via adaptive diversification of conformers in hosts expressing prion protein polymorphisms
por: Duque Velásquez, Camilo, et al.
Publicado: (2020)

Early detection of chronic wasting disease prions in urine of pre-symptomatic deer by real-time quaking-induced conversion assay
por: John, Theodore R., et al.
Publicado: (2013)

Surveillance for Prion Disease in Cervids, Germany
por: Schettler, Elvira, et al.
Publicado: (2006)

Early and Non-Invasive Detection of Chronic Wasting Disease Prions in Elk Feces by Real-Time Quaking Induced Conversion
por: Cheng, Yo Ching, et al.
Publicado: (2016)

Rapid Antemortem Detection of CWD Prions in Deer Saliva
por: Henderson, Davin M., et al.
Publicado: (2013)

Gene-edited murine cell lines for propagation of chronic wasting disease prions
por: Walia, Rupali, et al.
Publicado: (2019)

Combining autophagy stimulators and cellulose ethers for therapy against prion disease
por: Abdulrahman, Basant A., et al.
Publicado: (2019)

Immunization of cervidized transgenic mice with multimeric deer prion protein induces self-antibodies that antagonize chronic wasting disease infectivity in vitro
por: Abdelaziz, Dalia H., et al.
Publicado: (2017)

Involvement of N- and C-terminal region of recombinant cervid prion protein in its reactivity to CWD and atypical BSE prions in real-time quaking-induced conversion reaction in the presence of high concentrations of tissue homogenates
por: Suzuki, Akio, et al.
Publicado: (2020)

Prion infection impairs lysosomal degradation capacity by interfering with rab7 membrane attachment in neuronal cells
por: Shim, Su Yeon, et al.
Publicado: (2016)

Peptide aptamer targeting Aβ–PrP–Fyn axis reduces Alzheimer’s disease pathologies in 5XFAD transgenic mouse model
por: Ali, Tahir, et al.
Publicado: (2023)

A genome-wide survey for prion-regulated miRNAs associated with cholesterol homeostasis
por: Montag, Judith, et al.
Publicado: (2012)

Oral vaccination as a potential strategy to manage chronic wasting disease in wild cervid populations
por: Napper, Scott, et al.
Publicado: (2023)

Assessing Proteinase K Resistance of Fish Prion Proteins in a Scrapie-Infected Mouse Neuroblastoma Cell Line
por: Salta, Evgenia, et al.
Publicado: (2014)

The celecoxib derivatives AR-12 and AR-14 induce autophagy and clear prion-infected cells from prions
por: Abdulrahman, Basant A., et al.
Publicado: (2017)

Detection of CWD Prions in Urine and Saliva of Deer by Transgenic Mouse Bioassay
por: Haley, Nicholas J., et al.
Publicado: (2009)

No evidence of uptake or propagation of reindeer CWD prions in environmentally exposed sheep
por: Harpaz, Erez, et al.
Publicado: (2022)

Chronic Wasting Disease in Cervids: Implications for Prion Transmission to Humans and Other Animal Species
por: Osterholm, Michael T., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_a99rs56bc6cq3n357n3na6o8aj