Identification of a binding site on soluble RANKL that can be targeted to inhibit soluble RANK-RANKL interactions and treat osteoporosis

One of the major challenges for discovering protein-protein interaction inhibitors is identifying selective and druggable binding sites at the protein surface. Here, we report an approach to identify a small molecular binding site to selectively inhibit the interaction of soluble RANKL and RANK for...

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Detalles Bibliográficos
Autores principales: Huang, Dane, Zhao, Chao, Li, Ruyue, Chen, Bingyi, Zhang, Yuting, Sun, Zhejun, Wei, Junkang, Zhou, Huihao, Gu, Qiong, Xu, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468151/
https://www.ncbi.nlm.nih.gov/pubmed/36097003
http://dx.doi.org/10.1038/s41467-022-33006-4

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