Basal ganglia engagement during REM sleep movements in Parkinson’s disease

To elucidate the role of the basal ganglia during REM sleep movements in Parkinson’s disease (PD) we recorded pallidal neural activity from four PD patients. Unlike desynchronization commonly observed during wakeful movements, beta oscillations (13–35 Hz) synchronized during REM sleep movements; fur...

Descripción completa

Detalles Bibliográficos
Autores principales: Verma, Ajay K., Acosta Lenis, Sergio Francisco, Aman, Joshua E., Sanabria, David Escobar, Wang, Jing, Pearson, Amy, Hill, Meghan, Patriat, Remi, Schrock, Lauren E., Cooper, Scott E., Park, Michael C., Harel, Noam, Howell, Michael J., MacKinnon, Colum D., Vitek, Jerrold L., Johnson, Luke A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468156/
https://www.ncbi.nlm.nih.gov/pubmed/36097027
http://dx.doi.org/10.1038/s41531-022-00382-z
Descripción
Sumario:To elucidate the role of the basal ganglia during REM sleep movements in Parkinson’s disease (PD) we recorded pallidal neural activity from four PD patients. Unlike desynchronization commonly observed during wakeful movements, beta oscillations (13–35 Hz) synchronized during REM sleep movements; furthermore, high-frequency oscillations (150–350 Hz) synchronized during movement irrespective of sleep-wake states. Our results demonstrate differential engagement of the basal ganglia during REM sleep and awake movements.

Ejemplares similares