Cargando…

Direct conversion of human umbilical cord mesenchymal stem cells into retinal pigment epithelial cells for treatment of retinal degeneration

Age-related macular degeneration (AMD) is a major vision-threatening disease. Although mesenchymal stem cells (MSCs) exhibit beneficial neural protective effects, their limited differentiation capacity in vivo attenuates their therapeutic function. Therefore, the differentiation of MSCs into retinal...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhu, Xiaoman, Chen, Zhiyang, Wang, Li, Ou, Qingjian, Feng, Zhong, Xiao, Honglei, Shen, Qi, Li, Yingao, Jin, Caixia, Xu, Jing-Ying, Gao, Furong, Wang, Juan, Zhang, Jingfa, Zhang, Jieping, Xu, Zhiguo, Xu, Guo-Tong, Lu, Lixia, Tian, Haibin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468174/ https://www.ncbi.nlm.nih.gov/pubmed/36096985 http://dx.doi.org/10.1038/s41419-022-05199-5

Ejemplares similares

Induced retinal pigment epithelial cells with anti-epithelial-to-mesenchymal transition ability delay retinal degeneration
por: Tian, Haibin, et al.
Publicado: (2022)

Transplantation Site Affects the Outcomes of Adipose-Derived Stem Cell-Based Therapy for Retinal Degeneration
por: Hu, Chengyu, et al.
Publicado: (2020)

Effectively Intervening Epithelial-Mesenchymal Transition of Retinal Pigment Epithelial Cells With a Combination of ROCK and TGF-β Signaling Inhibitors
por: Chen, Yi, et al.
Publicado: (2021)

The combination of bFGF and CHIR99021 maintains stable self-renewal of mouse adult retinal progenitor cells
por: Jin, Caixia, et al.
Publicado: (2018)

Subconjunctival injection of human umbilical cord mesenchymal stem cells alleviates experimental allergic conjunctivitis via regulating T cell response
por: Li, Dongli, et al.
Publicado: (2023)

Chaperone-mediated autophagy plays an important role in regulating retinal progenitor cell homeostasis
por: Jin, Caixia, et al.
Publicado: (2022)

Glia Maturation Factor Beta as a Novel Biomarker and Therapeutic Target for Hepatocellular Carcinoma
por: Sun, Wan, et al.
Publicado: (2021)

OFD1, as a Ciliary Protein, Exhibits Neuroprotective Function in Photoreceptor Degeneration Models
por: Wang, Juan, et al.
Publicado: (2016)

Glia maturation factor-β induces ferroptosis by impairing chaperone-mediated autophagic degradation of ACSL4 in early diabetic retinopathy
por: Liu, Caiying, et al.
Publicado: (2022)

Involvement of the Retinal Pigment Epithelium in the Development of Retinal Lattice Degeneration
por: Mizuno, Hiroshi, et al.
Publicado: (2020)

Glia Maturation Factor β as a Novel Independent Prognostic Biomarker and Potential Therapeutic Target of Kidney Renal Clear Cell Carcinoma
por: Zhu, Tong, et al.
Publicado: (2022)

Transplantation of rat embryonic stem cell-derived retinal progenitor cells preserves the retinal structure and function in rat retinal degeneration
por: Qu, Zepeng, et al.
Publicado: (2015)

Protein Kinase A Inhibitor H89 Attenuates Experimental Proliferative Vitreoretinopathy
por: Lyu, Yali, et al.
Publicado: (2020)

Human Amniotic Epithelial Stem Cell-Derived Retinal Pigment Epithelium Cells Repair Retinal Degeneration
por: Li, Jinying, et al.
Publicado: (2021)

Role of Mitochondria in Retinal Pigment Epithelial Aging and Degeneration
por: Tong, Yao, et al.
Publicado: (2022)

Paraoxonase 2 Deficiency Causes Mitochondrial Dysfunction in Retinal Pigment Epithelial Cells and Retinal Degeneration in Mice
por: Sreekumar, Parameswaran Gangadharan, et al.
Publicado: (2023)

Inhibitory Effect of Bone Morphogenetic Protein 4 in Retinal Pigment Epithelial-Mesenchymal Transition
por: Yao, Haipei, et al.
Publicado: (2016)

NLRP3 Upregulation in Retinal Pigment Epithelium in Age-Related Macular Degeneration
por: Wang, Yujuan, et al.
Publicado: (2016)

Retinal pigment epithelial detachments and tears, and progressive retinal degeneration in light chain deposition disease
por: Spielberg, Leigh H, et al.
Publicado: (2013)

Dorsal-Ventral Differences in Retinal Structure in the Pigmented Royal College of Surgeons Model of Retinal Degeneration
por: Greferath, Una, et al.
Publicado: (2021)

BMSC-derived extracellular vesicles intervened the pathogenic changes of scleroderma in mice through miRNAs
por: Jin, Jiahui, et al.
Publicado: (2021)

Spermidine Oxidation-Mediated Degeneration of Retinal Pigment Epithelium in Rats
por: Ohashi, Koji, et al.
Publicado: (2017)

Retinal Pigment Epithelial Detachment in Age-Related Macular Degeneration
por: Karampelas, Michael, et al.
Publicado: (2020)

Tracking the Transplanted Neurosphere in Retinal Pigment Epithelium Degeneration Model
por: Kadkhodaeian, Hamid Aboutaleb, et al.
Publicado: (2021)

Replenishing Age-Related Decline of IRAK-M Expression in Retinal Pigment Epithelium Attenuates Outer Retinal Degeneration
por: Liu, Jian, et al.
Publicado: (2023)

Identification of Novel Key Molecular Signatures in the Pathogenesis of Experimental Diabetic Kidney Disease
por: Diao, Meng, et al.
Publicado: (2022)

Human amniotic epithelial cell-derived extracellular vesicles provide an extracellular matrix-based microenvironment for corneal injury repair
por: Hu, Shuqin, et al.
Publicado: (2022)

Scaffolds for retinal pigment epithelial cell transplantation in age-related macular degeneration
por: White, Corina E, et al.
Publicado: (2017)

Hydroquinone predisposes for retinal pigment epithelial (RPE) cell degeneration in inflammatory conditions
por: Bhattarai, Niina, et al.
Publicado: (2022)

Novel Localization of Peripherin 2, the Photoreceptor-Specific Retinal Degeneration Slow Protein, in Retinal Pigment Epithelium
por: Uhl, Patrizia B., et al.
Publicado: (2015)

Retinal Pigment Epithelial and Outer Retinal Atrophy in Age-Related Macular Degeneration: Correlation with Macular Function
por: Savastano, Maria C., et al.
Publicado: (2020)

Erythropoietin Gene Therapy Delays Retinal Degeneration Resulting from Oxidative Stress in the Retinal Pigment Epithelium
por: Biswal, Manas R., et al.
Publicado: (2021)

Inflammation of the retinal pigment epithelium drives early-onset photoreceptor degeneration in Mertk-associated retinitis pigmentosa
por: Mercau, Maria E., et al.
Publicado: (2023)

Intravitreal Injection of Human Retinal Progenitor Cells for Treatment of Retinal Degeneration
por: Wang, Zhuoshi, et al.
Publicado: (2020)

Adult human periodontal ligament-derived stem cells delay retinal degeneration and maintain retinal function in RCS rats
por: Huang, Li, et al.
Publicado: (2017)

Retinoid Metabolism in the Degeneration of Pten-Deficient Mouse Retinal Pigment Epithelium
por: Kim, You-Joung, et al.
Publicado: (2021)

Glia maturation factor beta deficiency protects against diabetic osteoporosis by suppressing osteoclast hyperactivity
por: Shi, Si, et al.
Publicado: (2023)

Retinal pigment epithelial tears following ranibizumab therapy for fibrovascular retinal pigment epithelial detachment due to occult age-related macular degeneration
por: Figurska, Małgorzata
Publicado: (2012)

Direct conversion of human fibroblasts into retinal pigment epithelium-like cells by defined factors
por: Zhang, Kejing, et al.
Publicado: (2014)

Directional protein secretion by the retinal pigment epithelium: roles in retinal health and the development of age-related macular degeneration
por: Kay, Paul, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_dapnuuo1sqerf29obkmddpq4i8