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Mutated Pkhd1 alone is sufficient to cause autoimmune biliary disease on the nonobese diabetic (NOD) genetic background

We previously reported that nonobese diabetic (NOD) congenic mice (NOD.c3c4 mice) developed an autoimmune biliary disease (ABD) with similarities to human primary biliary cholangitis (PBC), including anti-mitochondrial antibodies and organ-specific biliary lymphocytic infiltrates. We narrowed the po...

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Detalles Bibliográficos
Autores principales: Adams, David E., Heuer, Luke S., Rojas, Manuel, Zhang, Weici, Ridgway, William M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468241/
https://www.ncbi.nlm.nih.gov/pubmed/36097289
http://dx.doi.org/10.1007/s00251-022-01276-3

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