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Survival benefit of primary and metastatic tumor resection for colon cancer with liver metastases: A population based, propensity score-matched study

BACKGROUND: Colon cancer remains one of the most common malignancies and we aimed to evaluate whether surgery has an effect on the survival of metastatic colon patients. METHODS: We analyzed 7,583 metastatic colon patients from the Surveillance, Epidemiology, between January 2010 and December 2015....

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Autores principales: Qiao, Yunfeng, Li, Huijun, Fu, Jinge, You, Shuping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468248/
https://www.ncbi.nlm.nih.gov/pubmed/36111222
http://dx.doi.org/10.3389/fsurg.2022.959826
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author Qiao, Yunfeng
Qiao, Yunfeng
Li, Huijun
Fu, Jinge
You, Shuping
author_facet Qiao, Yunfeng
Qiao, Yunfeng
Li, Huijun
Fu, Jinge
You, Shuping
author_sort Qiao, Yunfeng
collection PubMed
description BACKGROUND: Colon cancer remains one of the most common malignancies and we aimed to evaluate whether surgery has an effect on the survival of metastatic colon patients. METHODS: We analyzed 7,583 metastatic colon patients from the Surveillance, Epidemiology, between January 2010 and December 2015. Using Cox proportional hazards models and Kaplan-Meier curves, the overall survival rate (OS) and cancer-specific survival rate and End Results (SEER) registry (CSS) months (m) were evaluated with corresponding 95% confidence intervals (95% CIs). Propensity score matching (PSM) was performed to adjust for potential baseline confounding of all comparison groups. RESULTS: In general, receiving both primary and metastatic tumor resection (PMTR) remarkably improved OS and CSS compared with only primary tumor resection (PTR) after PS matching (PSM) (P < 0.05), with a significantly improved OS (HR = 0.74, 95%CI = 0.69–0.80) and CSS (HR = 0.71, 95%CI = 0.66–0.76) in all stage M1 colon patients. The stratification analysis indicated a significant difference between OS and CSS in M1a and M1b stages. After PSM, PMTR was found to be associated with remarkably improved OS and CSS for patients with liver metastases but not associated with OS and CSS of patients with lung metastases in both M1a and M1b stage. CONCLUSIONS: The results from this large SEER cohort supported PMTR might improve the survival of colon patients with liver metastases on the basis of chemotherapy.
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spelling pubmed-94682482022-09-14 Survival benefit of primary and metastatic tumor resection for colon cancer with liver metastases: A population based, propensity score-matched study Qiao, Yunfeng Qiao, Yunfeng Li, Huijun Fu, Jinge You, Shuping Front Surg Surgery BACKGROUND: Colon cancer remains one of the most common malignancies and we aimed to evaluate whether surgery has an effect on the survival of metastatic colon patients. METHODS: We analyzed 7,583 metastatic colon patients from the Surveillance, Epidemiology, between January 2010 and December 2015. Using Cox proportional hazards models and Kaplan-Meier curves, the overall survival rate (OS) and cancer-specific survival rate and End Results (SEER) registry (CSS) months (m) were evaluated with corresponding 95% confidence intervals (95% CIs). Propensity score matching (PSM) was performed to adjust for potential baseline confounding of all comparison groups. RESULTS: In general, receiving both primary and metastatic tumor resection (PMTR) remarkably improved OS and CSS compared with only primary tumor resection (PTR) after PS matching (PSM) (P < 0.05), with a significantly improved OS (HR = 0.74, 95%CI = 0.69–0.80) and CSS (HR = 0.71, 95%CI = 0.66–0.76) in all stage M1 colon patients. The stratification analysis indicated a significant difference between OS and CSS in M1a and M1b stages. After PSM, PMTR was found to be associated with remarkably improved OS and CSS for patients with liver metastases but not associated with OS and CSS of patients with lung metastases in both M1a and M1b stage. CONCLUSIONS: The results from this large SEER cohort supported PMTR might improve the survival of colon patients with liver metastases on the basis of chemotherapy. Frontiers Media S.A. 2022-08-30 /pmc/articles/PMC9468248/ /pubmed/36111222 http://dx.doi.org/10.3389/fsurg.2022.959826 Text en © 2022 Qiao, Qiao, Li, Fu and You. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Surgery
Qiao, Yunfeng
Qiao, Yunfeng
Li, Huijun
Fu, Jinge
You, Shuping
Survival benefit of primary and metastatic tumor resection for colon cancer with liver metastases: A population based, propensity score-matched study
title Survival benefit of primary and metastatic tumor resection for colon cancer with liver metastases: A population based, propensity score-matched study
title_full Survival benefit of primary and metastatic tumor resection for colon cancer with liver metastases: A population based, propensity score-matched study
title_fullStr Survival benefit of primary and metastatic tumor resection for colon cancer with liver metastases: A population based, propensity score-matched study
title_full_unstemmed Survival benefit of primary and metastatic tumor resection for colon cancer with liver metastases: A population based, propensity score-matched study
title_short Survival benefit of primary and metastatic tumor resection for colon cancer with liver metastases: A population based, propensity score-matched study
title_sort survival benefit of primary and metastatic tumor resection for colon cancer with liver metastases: a population based, propensity score-matched study
topic Surgery
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468248/
https://www.ncbi.nlm.nih.gov/pubmed/36111222
http://dx.doi.org/10.3389/fsurg.2022.959826
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