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Body Size at Different Ages and Risk of 6 Cancers: A Mendelian Randomization and Prospective Cohort Study
It is unclear if body weight in early life affects cancer risk independently of adult body weight. To investigate this question for 6 obesity-related cancers, we performed univariable and multivariable analyses using 1) Mendelian randomization (MR) analysis and 2) longitudinal analyses in prospectiv...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468294/ https://www.ncbi.nlm.nih.gov/pubmed/35438160 http://dx.doi.org/10.1093/jnci/djac061 |
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| author | Mariosa, Daniela Smith-Byrne, Karl Richardson, Tom G Ferrari, Pietro Gunter, Marc J Papadimitriou, Nikos Murphy, Neil Christakoudi, Sofia Tsilidis, Konstantinos K Riboli, Elio Muller, David Purdue, Mark P Chanock, Stephen J Hung, Rayjean J Amos, Christopher I O’Mara, Tracy A Amiano, Pilar Pasanisi, Fabrizio Rodriguez-Barranco, Miguel Krogh, Vittorio Tjønneland, Anne Halkjær, Jytte Perez-Cornago, Aurora Chirlaque, María-Dolores Skeie, Guri Rylander, Charlotta Borch, Kristin Benjaminsen Aune, Dagfinn Heath, Alicia K Ward, Heather A Schulze, Matthias Bonet, Catalina Weiderpass, Elisabete Davey Smith, George Brennan, Paul Johansson, Mattias |
| author_facet | Mariosa, Daniela Smith-Byrne, Karl Richardson, Tom G Ferrari, Pietro Gunter, Marc J Papadimitriou, Nikos Murphy, Neil Christakoudi, Sofia Tsilidis, Konstantinos K Riboli, Elio Muller, David Purdue, Mark P Chanock, Stephen J Hung, Rayjean J Amos, Christopher I O’Mara, Tracy A Amiano, Pilar Pasanisi, Fabrizio Rodriguez-Barranco, Miguel Krogh, Vittorio Tjønneland, Anne Halkjær, Jytte Perez-Cornago, Aurora Chirlaque, María-Dolores Skeie, Guri Rylander, Charlotta Borch, Kristin Benjaminsen Aune, Dagfinn Heath, Alicia K Ward, Heather A Schulze, Matthias Bonet, Catalina Weiderpass, Elisabete Davey Smith, George Brennan, Paul Johansson, Mattias |
| author_sort | Mariosa, Daniela |
| collection | PubMed |
| description | It is unclear if body weight in early life affects cancer risk independently of adult body weight. To investigate this question for 6 obesity-related cancers, we performed univariable and multivariable analyses using 1) Mendelian randomization (MR) analysis and 2) longitudinal analyses in prospective cohorts. Both the MR and longitudinal analyses indicated that larger early life body size was associated with higher risk of endometrial (odds ratio(MR) = 1.61, 95% confidence interval = 1.23 to 2.11) and kidney (odds ratio(MR) = 1.40, 95% confidence interval = 1.09 to 1.80) cancer. These associations were attenuated after accounting for adult body size in both the MR and cohort analyses. Early life body mass index (BMI) was not consistently associated with the other investigated cancers. The lack of clear independent risk associations suggests that early life BMI influences endometrial and kidney cancer risk mainly through pathways that are common with adult BMI. |
| format | Online Article Text |
| id | pubmed-9468294 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | Oxford University Press |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-94682942022-09-13 Body Size at Different Ages and Risk of 6 Cancers: A Mendelian Randomization and Prospective Cohort Study Mariosa, Daniela Smith-Byrne, Karl Richardson, Tom G Ferrari, Pietro Gunter, Marc J Papadimitriou, Nikos Murphy, Neil Christakoudi, Sofia Tsilidis, Konstantinos K Riboli, Elio Muller, David Purdue, Mark P Chanock, Stephen J Hung, Rayjean J Amos, Christopher I O’Mara, Tracy A Amiano, Pilar Pasanisi, Fabrizio Rodriguez-Barranco, Miguel Krogh, Vittorio Tjønneland, Anne Halkjær, Jytte Perez-Cornago, Aurora Chirlaque, María-Dolores Skeie, Guri Rylander, Charlotta Borch, Kristin Benjaminsen Aune, Dagfinn Heath, Alicia K Ward, Heather A Schulze, Matthias Bonet, Catalina Weiderpass, Elisabete Davey Smith, George Brennan, Paul Johansson, Mattias J Natl Cancer Inst Brief Communications It is unclear if body weight in early life affects cancer risk independently of adult body weight. To investigate this question for 6 obesity-related cancers, we performed univariable and multivariable analyses using 1) Mendelian randomization (MR) analysis and 2) longitudinal analyses in prospective cohorts. Both the MR and longitudinal analyses indicated that larger early life body size was associated with higher risk of endometrial (odds ratio(MR) = 1.61, 95% confidence interval = 1.23 to 2.11) and kidney (odds ratio(MR) = 1.40, 95% confidence interval = 1.09 to 1.80) cancer. These associations were attenuated after accounting for adult body size in both the MR and cohort analyses. Early life body mass index (BMI) was not consistently associated with the other investigated cancers. The lack of clear independent risk associations suggests that early life BMI influences endometrial and kidney cancer risk mainly through pathways that are common with adult BMI. Oxford University Press 2022-04-19 /pmc/articles/PMC9468294/ /pubmed/35438160 http://dx.doi.org/10.1093/jnci/djac061 Text en © World Health Organization, 2022. All rights reserved. The World Health Organization has granted the Publisher permission for the reproduction of this article. https://creativecommons.org/licenses/by/3.0/igo/This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 IGO License (https://creativecommons.org/licenses/by/3.0/igo/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Brief Communications Mariosa, Daniela Smith-Byrne, Karl Richardson, Tom G Ferrari, Pietro Gunter, Marc J Papadimitriou, Nikos Murphy, Neil Christakoudi, Sofia Tsilidis, Konstantinos K Riboli, Elio Muller, David Purdue, Mark P Chanock, Stephen J Hung, Rayjean J Amos, Christopher I O’Mara, Tracy A Amiano, Pilar Pasanisi, Fabrizio Rodriguez-Barranco, Miguel Krogh, Vittorio Tjønneland, Anne Halkjær, Jytte Perez-Cornago, Aurora Chirlaque, María-Dolores Skeie, Guri Rylander, Charlotta Borch, Kristin Benjaminsen Aune, Dagfinn Heath, Alicia K Ward, Heather A Schulze, Matthias Bonet, Catalina Weiderpass, Elisabete Davey Smith, George Brennan, Paul Johansson, Mattias Body Size at Different Ages and Risk of 6 Cancers: A Mendelian Randomization and Prospective Cohort Study |
| title | Body Size at Different Ages and Risk of 6 Cancers: A Mendelian Randomization and Prospective Cohort Study |
| title_full | Body Size at Different Ages and Risk of 6 Cancers: A Mendelian Randomization and Prospective Cohort Study |
| title_fullStr | Body Size at Different Ages and Risk of 6 Cancers: A Mendelian Randomization and Prospective Cohort Study |
| title_full_unstemmed | Body Size at Different Ages and Risk of 6 Cancers: A Mendelian Randomization and Prospective Cohort Study |
| title_short | Body Size at Different Ages and Risk of 6 Cancers: A Mendelian Randomization and Prospective Cohort Study |
| title_sort | body size at different ages and risk of 6 cancers: a mendelian randomization and prospective cohort study |
| topic | Brief Communications |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468294/ https://www.ncbi.nlm.nih.gov/pubmed/35438160 http://dx.doi.org/10.1093/jnci/djac061 |
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