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Implemented occupational health surveillance limits the spread of SARS-CoV-2 Omicron at the workplace

The global spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has put an enormous pressure on human societies, at both health and economic levels. Early diagnosis of SARS-CoV-2, the causative agent of 2019 coronavirus disease (COVID-19), has proved an efficient method to rapi...

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Autores principales: Gesto, João Silveira Moledo, Cabanelas, Adriana, Farjun, Bruna, dos Santos, Monique Cristina, Fidalgo-Neto, Antonio A., Kuriyama, Sergio N., Souza, Thiago Moreno L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468326/
https://www.ncbi.nlm.nih.gov/pubmed/36111122
http://dx.doi.org/10.3389/fmed.2022.910176
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author Gesto, João Silveira Moledo
Cabanelas, Adriana
Farjun, Bruna
dos Santos, Monique Cristina
Fidalgo-Neto, Antonio A.
Kuriyama, Sergio N.
Souza, Thiago Moreno L.
author_facet Gesto, João Silveira Moledo
Cabanelas, Adriana
Farjun, Bruna
dos Santos, Monique Cristina
Fidalgo-Neto, Antonio A.
Kuriyama, Sergio N.
Souza, Thiago Moreno L.
author_sort Gesto, João Silveira Moledo
collection PubMed
description The global spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has put an enormous pressure on human societies, at both health and economic levels. Early diagnosis of SARS-CoV-2, the causative agent of 2019 coronavirus disease (COVID-19), has proved an efficient method to rapidly isolate positive individuals and reduce transmission rates, thus alleviating its negative impact on society’s well-being and economic growth. In this work, through a coordinated and centralized effort to monitor SARS-CoV-2 circulation in companies from the State of Rio de Janeiro, Brazil, we have detected and linked an early rise of infection rates in January 2022 to the introduction of the Omicron variant of concern (VoC) (BA.1). Interestingly, when the Omicron genomic isolates were compared to correlates from public datasets, it was revealed that introduction events were multiple, with possible migration routes mapping to: Mali; Oman and United States; and Italy, Latin America, and United States. In addition, we have built a haplotype network with our genomic dataset and found no strong evidence of transmission chains, between and within companies. Considering Omicron’s particularly high transmissibility, and that most of our samples (>87%) arose from 3 out of 10 companies, these findings suggest that workers from such environments were exposed to SARS-CoV-2 outside their company boundaries. Thus, using a mixed strategy in which quick molecular diagnosis finds support in comprehensive genomic analysis, we have shown that a successfully implemented occupational health program should contribute to document emerging VoC and to limit the spread of SARS-CoV-2 at the workplace.
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spelling pubmed-94683262022-09-14 Implemented occupational health surveillance limits the spread of SARS-CoV-2 Omicron at the workplace Gesto, João Silveira Moledo Cabanelas, Adriana Farjun, Bruna dos Santos, Monique Cristina Fidalgo-Neto, Antonio A. Kuriyama, Sergio N. Souza, Thiago Moreno L. Front Med (Lausanne) Medicine The global spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has put an enormous pressure on human societies, at both health and economic levels. Early diagnosis of SARS-CoV-2, the causative agent of 2019 coronavirus disease (COVID-19), has proved an efficient method to rapidly isolate positive individuals and reduce transmission rates, thus alleviating its negative impact on society’s well-being and economic growth. In this work, through a coordinated and centralized effort to monitor SARS-CoV-2 circulation in companies from the State of Rio de Janeiro, Brazil, we have detected and linked an early rise of infection rates in January 2022 to the introduction of the Omicron variant of concern (VoC) (BA.1). Interestingly, when the Omicron genomic isolates were compared to correlates from public datasets, it was revealed that introduction events were multiple, with possible migration routes mapping to: Mali; Oman and United States; and Italy, Latin America, and United States. In addition, we have built a haplotype network with our genomic dataset and found no strong evidence of transmission chains, between and within companies. Considering Omicron’s particularly high transmissibility, and that most of our samples (>87%) arose from 3 out of 10 companies, these findings suggest that workers from such environments were exposed to SARS-CoV-2 outside their company boundaries. Thus, using a mixed strategy in which quick molecular diagnosis finds support in comprehensive genomic analysis, we have shown that a successfully implemented occupational health program should contribute to document emerging VoC and to limit the spread of SARS-CoV-2 at the workplace. Frontiers Media S.A. 2022-08-30 /pmc/articles/PMC9468326/ /pubmed/36111122 http://dx.doi.org/10.3389/fmed.2022.910176 Text en Copyright © 2022 Gesto, Cabanelas, Farjun, dos Santos, Fidalgo-Neto, Kuriyama and Souza. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Gesto, João Silveira Moledo
Cabanelas, Adriana
Farjun, Bruna
dos Santos, Monique Cristina
Fidalgo-Neto, Antonio A.
Kuriyama, Sergio N.
Souza, Thiago Moreno L.
Implemented occupational health surveillance limits the spread of SARS-CoV-2 Omicron at the workplace
title Implemented occupational health surveillance limits the spread of SARS-CoV-2 Omicron at the workplace
title_full Implemented occupational health surveillance limits the spread of SARS-CoV-2 Omicron at the workplace
title_fullStr Implemented occupational health surveillance limits the spread of SARS-CoV-2 Omicron at the workplace
title_full_unstemmed Implemented occupational health surveillance limits the spread of SARS-CoV-2 Omicron at the workplace
title_short Implemented occupational health surveillance limits the spread of SARS-CoV-2 Omicron at the workplace
title_sort implemented occupational health surveillance limits the spread of sars-cov-2 omicron at the workplace
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468326/
https://www.ncbi.nlm.nih.gov/pubmed/36111122
http://dx.doi.org/10.3389/fmed.2022.910176
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