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A nano erythropoiesis stimulating agent for the treatment of anemia and associated disorders

The usual treatment for anemia and especially for anemia of inflammation (also called anemia of chronic disease) is supportive care with the target of improving the lifestyle of the patients. There is no effective medication to date for proper management. As the inflammation, erythropoiesis, and oxi...

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Autores principales: Das, Monojit, Mondal, Susmita, Ghosh, Ria, Biswas, Pritam, Moussa, Ziad, Darbar, Soumendra, Ahmed, Saleh A., Das, Anjan Kumar, Bhattacharya, Siddhartha Sankar, Pal, Debasish, Mallick, Asim Kumar, Chakrabarti, Prantar, Kundu, Jayanta Kumar, Adhikari, Aniruddha, Pal, Samir Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468392/
https://www.ncbi.nlm.nih.gov/pubmed/36111254
http://dx.doi.org/10.1016/j.isci.2022.105021
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author Das, Monojit
Mondal, Susmita
Ghosh, Ria
Biswas, Pritam
Moussa, Ziad
Darbar, Soumendra
Ahmed, Saleh A.
Das, Anjan Kumar
Bhattacharya, Siddhartha Sankar
Pal, Debasish
Mallick, Asim Kumar
Chakrabarti, Prantar
Kundu, Jayanta Kumar
Adhikari, Aniruddha
Pal, Samir Kumar
author_facet Das, Monojit
Mondal, Susmita
Ghosh, Ria
Biswas, Pritam
Moussa, Ziad
Darbar, Soumendra
Ahmed, Saleh A.
Das, Anjan Kumar
Bhattacharya, Siddhartha Sankar
Pal, Debasish
Mallick, Asim Kumar
Chakrabarti, Prantar
Kundu, Jayanta Kumar
Adhikari, Aniruddha
Pal, Samir Kumar
author_sort Das, Monojit
collection PubMed
description The usual treatment for anemia and especially for anemia of inflammation (also called anemia of chronic disease) is supportive care with the target of improving the lifestyle of the patients. There is no effective medication to date for proper management. As the inflammation, erythropoiesis, and oxidative stress are the major concerns in this case, it inspired us to use a nano-erythropoietin stimulating agent (nano-ESA) made up of a nano-complex of manganese and citrate (Mn-citrate nano-complex), which has been hypothesized to have excellent antioxidant and anti-inflammatory mechanisms. Single oral dose of the nano-ESA efficiently prevented the onset of anemia as well as led to recovery from anemia in our phenylhydrazine (PHz)-intoxicated C57BL/6J mice model of anemia without any toxicological side effects. These preliminary findings may pave the way for an affordable and safe clinical use of the nano-ESA as a rapid recovery medication of anemia, especially anemia of inflammation.
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spelling pubmed-94683922022-09-14 A nano erythropoiesis stimulating agent for the treatment of anemia and associated disorders Das, Monojit Mondal, Susmita Ghosh, Ria Biswas, Pritam Moussa, Ziad Darbar, Soumendra Ahmed, Saleh A. Das, Anjan Kumar Bhattacharya, Siddhartha Sankar Pal, Debasish Mallick, Asim Kumar Chakrabarti, Prantar Kundu, Jayanta Kumar Adhikari, Aniruddha Pal, Samir Kumar iScience Article The usual treatment for anemia and especially for anemia of inflammation (also called anemia of chronic disease) is supportive care with the target of improving the lifestyle of the patients. There is no effective medication to date for proper management. As the inflammation, erythropoiesis, and oxidative stress are the major concerns in this case, it inspired us to use a nano-erythropoietin stimulating agent (nano-ESA) made up of a nano-complex of manganese and citrate (Mn-citrate nano-complex), which has been hypothesized to have excellent antioxidant and anti-inflammatory mechanisms. Single oral dose of the nano-ESA efficiently prevented the onset of anemia as well as led to recovery from anemia in our phenylhydrazine (PHz)-intoxicated C57BL/6J mice model of anemia without any toxicological side effects. These preliminary findings may pave the way for an affordable and safe clinical use of the nano-ESA as a rapid recovery medication of anemia, especially anemia of inflammation. Elsevier 2022-08-27 /pmc/articles/PMC9468392/ /pubmed/36111254 http://dx.doi.org/10.1016/j.isci.2022.105021 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Das, Monojit
Mondal, Susmita
Ghosh, Ria
Biswas, Pritam
Moussa, Ziad
Darbar, Soumendra
Ahmed, Saleh A.
Das, Anjan Kumar
Bhattacharya, Siddhartha Sankar
Pal, Debasish
Mallick, Asim Kumar
Chakrabarti, Prantar
Kundu, Jayanta Kumar
Adhikari, Aniruddha
Pal, Samir Kumar
A nano erythropoiesis stimulating agent for the treatment of anemia and associated disorders
title A nano erythropoiesis stimulating agent for the treatment of anemia and associated disorders
title_full A nano erythropoiesis stimulating agent for the treatment of anemia and associated disorders
title_fullStr A nano erythropoiesis stimulating agent for the treatment of anemia and associated disorders
title_full_unstemmed A nano erythropoiesis stimulating agent for the treatment of anemia and associated disorders
title_short A nano erythropoiesis stimulating agent for the treatment of anemia and associated disorders
title_sort nano erythropoiesis stimulating agent for the treatment of anemia and associated disorders
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468392/
https://www.ncbi.nlm.nih.gov/pubmed/36111254
http://dx.doi.org/10.1016/j.isci.2022.105021
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