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The imbalance between Type 17 T-cells and regulatory immune cell subsets in psoriasis vulgaris

Psoriasis vulgaris is a common inflammatory disease affecting 7.5 million adults just in the US. Previously, psoriasis immunopathogenesis has been viewed as the imbalance between CD4(+) T-helper 17 (Th17) cells and regulatory T-cells (Tregs). However, current paradigms are rapidly evolving as new te...

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Autores principales: Kim, Jaehwan, Moreno, Ariana, Krueger, James G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468415/
https://www.ncbi.nlm.nih.gov/pubmed/36110854
http://dx.doi.org/10.3389/fimmu.2022.1005115
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author Kim, Jaehwan
Moreno, Ariana
Krueger, James G.
author_facet Kim, Jaehwan
Moreno, Ariana
Krueger, James G.
author_sort Kim, Jaehwan
collection PubMed
description Psoriasis vulgaris is a common inflammatory disease affecting 7.5 million adults just in the US. Previously, psoriasis immunopathogenesis has been viewed as the imbalance between CD4(+) T-helper 17 (Th17) cells and regulatory T-cells (Tregs). However, current paradigms are rapidly evolving as new technologies to study immune cell subsets in the skin have been advanced. For example, recently minted single-cell RNA sequencing technology has provided the opportunity to compare highly differing transcriptomes of Type 17 T-cell (T17 cell) subsets depending on IL-17A vs. IL-17F expression. The expression of regulatory cytokines in T17 cell subsets provided evidence of T-cell plasticity between T17 cells and regulatory T-cells (Tregs) in humans. In addition to Tregs, other types of regulatory cells in the skin have been elucidated, including type 1 regulatory T-cells (Tr1 cells) and regulatory dendritic cells. More recently, investigators are attempting to apply single-cell technologies to clinical trials of biologics to test if monoclonal blockade of pathogenic T-cells will induce expansion of regulatory immune cell subsets involved in skin homeostasis.
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spelling pubmed-94684152022-09-14 The imbalance between Type 17 T-cells and regulatory immune cell subsets in psoriasis vulgaris Kim, Jaehwan Moreno, Ariana Krueger, James G. Front Immunol Immunology Psoriasis vulgaris is a common inflammatory disease affecting 7.5 million adults just in the US. Previously, psoriasis immunopathogenesis has been viewed as the imbalance between CD4(+) T-helper 17 (Th17) cells and regulatory T-cells (Tregs). However, current paradigms are rapidly evolving as new technologies to study immune cell subsets in the skin have been advanced. For example, recently minted single-cell RNA sequencing technology has provided the opportunity to compare highly differing transcriptomes of Type 17 T-cell (T17 cell) subsets depending on IL-17A vs. IL-17F expression. The expression of regulatory cytokines in T17 cell subsets provided evidence of T-cell plasticity between T17 cells and regulatory T-cells (Tregs) in humans. In addition to Tregs, other types of regulatory cells in the skin have been elucidated, including type 1 regulatory T-cells (Tr1 cells) and regulatory dendritic cells. More recently, investigators are attempting to apply single-cell technologies to clinical trials of biologics to test if monoclonal blockade of pathogenic T-cells will induce expansion of regulatory immune cell subsets involved in skin homeostasis. Frontiers Media S.A. 2022-08-30 /pmc/articles/PMC9468415/ /pubmed/36110854 http://dx.doi.org/10.3389/fimmu.2022.1005115 Text en Copyright © 2022 Kim, Moreno and Krueger https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Kim, Jaehwan
Moreno, Ariana
Krueger, James G.
The imbalance between Type 17 T-cells and regulatory immune cell subsets in psoriasis vulgaris
title The imbalance between Type 17 T-cells and regulatory immune cell subsets in psoriasis vulgaris
title_full The imbalance between Type 17 T-cells and regulatory immune cell subsets in psoriasis vulgaris
title_fullStr The imbalance between Type 17 T-cells and regulatory immune cell subsets in psoriasis vulgaris
title_full_unstemmed The imbalance between Type 17 T-cells and regulatory immune cell subsets in psoriasis vulgaris
title_short The imbalance between Type 17 T-cells and regulatory immune cell subsets in psoriasis vulgaris
title_sort imbalance between type 17 t-cells and regulatory immune cell subsets in psoriasis vulgaris
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468415/
https://www.ncbi.nlm.nih.gov/pubmed/36110854
http://dx.doi.org/10.3389/fimmu.2022.1005115
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