KIF11 manipulates SREBP2‐dependent mevalonate cross talk to promote tumor progression in pancreatic ductal adenocarcinoma

Cholesterol metabolism is highly correlated with risks of pancreatic ductal adenocarcinoma (PDAC). Nevertheless, the underlying mechanisms of activation of cholesterol biogenesis remain inconclusive. KIF11 is a key component of the bipolar spindle and expresses highly in various malignancies. Howeve...

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Detalles Bibliográficos
Autores principales: Gu, Xiang, Zhu, Qunshan, Tian, Guangyu, Song, Wenbo, Wang, Tao, Wang, Ali, Chen, Xiaojun, Qin, Songbing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
RESEARCH ARTICLES
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468433/
https://www.ncbi.nlm.nih.gov/pubmed/35619540
http://dx.doi.org/10.1002/cam4.4683

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