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Mesenchymal stem cell-derived exosomes in cancer therapy resistance: recent advances and therapeutic potential
Mesenchymal stem cells (MSCs) are multipotent stromal cells that can be obtained from various human tissues and organs. They can differentiate into a wide range of cell types, including osteoblasts, adipocytes and chondrocytes, thus exhibiting great potential in regenerative medicine. Numerous studi...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468526/ https://www.ncbi.nlm.nih.gov/pubmed/36100944 http://dx.doi.org/10.1186/s12943-022-01650-5 |
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author | Lin, Zhengjun Wu, Yanlin Xu, Yiting Li, Guoqing Li, Zhihong Liu, Tang |
author_facet | Lin, Zhengjun Wu, Yanlin Xu, Yiting Li, Guoqing Li, Zhihong Liu, Tang |
author_sort | Lin, Zhengjun |
collection | PubMed |
description | Mesenchymal stem cells (MSCs) are multipotent stromal cells that can be obtained from various human tissues and organs. They can differentiate into a wide range of cell types, including osteoblasts, adipocytes and chondrocytes, thus exhibiting great potential in regenerative medicine. Numerous studies have indicated that MSCs play critical roles in cancer biology. The crosstalk between tumour cells and MSCs has been found to regulate many tumour behaviours, such as proliferation, metastasis and epithelial-mesenchymal transition (EMT). Multiple lines of evidence have demonstrated that MSCs can secrete exosomes that can modulate the tumour microenvironment and play important roles in tumour development. Notably, very recent works have shown that mesenchymal stem cell-derived exosomes (MSC-derived exosomes) are critically involved in cancer resistance to chemotherapy agents, targeted-therapy drugs, radiotherapy and immunotherapy. In this review, we systematically summarized the emerging roles and detailed molecular mechanisms of MSC-derived exosomes in mediating cancer therapy resistance, thus providing novel insights into the clinical applications of MSC-derived exosomes in cancer management. |
format | Online Article Text |
id | pubmed-9468526 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-94685262022-09-13 Mesenchymal stem cell-derived exosomes in cancer therapy resistance: recent advances and therapeutic potential Lin, Zhengjun Wu, Yanlin Xu, Yiting Li, Guoqing Li, Zhihong Liu, Tang Mol Cancer Review Mesenchymal stem cells (MSCs) are multipotent stromal cells that can be obtained from various human tissues and organs. They can differentiate into a wide range of cell types, including osteoblasts, adipocytes and chondrocytes, thus exhibiting great potential in regenerative medicine. Numerous studies have indicated that MSCs play critical roles in cancer biology. The crosstalk between tumour cells and MSCs has been found to regulate many tumour behaviours, such as proliferation, metastasis and epithelial-mesenchymal transition (EMT). Multiple lines of evidence have demonstrated that MSCs can secrete exosomes that can modulate the tumour microenvironment and play important roles in tumour development. Notably, very recent works have shown that mesenchymal stem cell-derived exosomes (MSC-derived exosomes) are critically involved in cancer resistance to chemotherapy agents, targeted-therapy drugs, radiotherapy and immunotherapy. In this review, we systematically summarized the emerging roles and detailed molecular mechanisms of MSC-derived exosomes in mediating cancer therapy resistance, thus providing novel insights into the clinical applications of MSC-derived exosomes in cancer management. BioMed Central 2022-09-13 /pmc/articles/PMC9468526/ /pubmed/36100944 http://dx.doi.org/10.1186/s12943-022-01650-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Lin, Zhengjun Wu, Yanlin Xu, Yiting Li, Guoqing Li, Zhihong Liu, Tang Mesenchymal stem cell-derived exosomes in cancer therapy resistance: recent advances and therapeutic potential |
title | Mesenchymal stem cell-derived exosomes in cancer therapy resistance: recent advances and therapeutic potential |
title_full | Mesenchymal stem cell-derived exosomes in cancer therapy resistance: recent advances and therapeutic potential |
title_fullStr | Mesenchymal stem cell-derived exosomes in cancer therapy resistance: recent advances and therapeutic potential |
title_full_unstemmed | Mesenchymal stem cell-derived exosomes in cancer therapy resistance: recent advances and therapeutic potential |
title_short | Mesenchymal stem cell-derived exosomes in cancer therapy resistance: recent advances and therapeutic potential |
title_sort | mesenchymal stem cell-derived exosomes in cancer therapy resistance: recent advances and therapeutic potential |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468526/ https://www.ncbi.nlm.nih.gov/pubmed/36100944 http://dx.doi.org/10.1186/s12943-022-01650-5 |
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