New-onset systemic lupus erythematosus following BNT162b2 mRNA COVID-19 vaccine: a case series and literature review

Emerging data evaluated the possible link between the Coronavirus 19 (COVID-19) vaccine and acute flares of rheumatic autoimmune diseases. However, the association between the COVID-19 vaccine and the development of de-novo rheumatic autoimmune diseases remained unclear. We report the first case ser...

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Autores principales: Sagy, Iftach, Zeller, Lior, Raviv, Yael, Porges, Tzvika, Bieber, Amir, Abu-Shakra, Mahmoud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Case Based Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468534/
https://www.ncbi.nlm.nih.gov/pubmed/36098769
http://dx.doi.org/10.1007/s00296-022-05203-3
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author Sagy, Iftach
Zeller, Lior
Raviv, Yael
Porges, Tzvika
Bieber, Amir
Abu-Shakra, Mahmoud
author_facet Sagy, Iftach
Zeller, Lior
Raviv, Yael
Porges, Tzvika
Bieber, Amir
Abu-Shakra, Mahmoud
author_sort Sagy, Iftach
collection PubMed
description Emerging data evaluated the possible link between the Coronavirus 19 (COVID-19) vaccine and acute flares of rheumatic autoimmune diseases. However, the association between the COVID-19 vaccine and the development of de-novo rheumatic autoimmune diseases remained unclear. We report the first case series of three male patients who developed new-onset systemic lupus erythematosus following receiving Pfizer BNT162b2 mRNA vaccination. The clinical characteristics share some similarities with drug-induced lupus. More patients with SLE following COVID-19 may be diagnosed in the future. Additional studies will provide more significant insights into the possible immunogenic influence of the COVID-19 vaccine. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00296-022-05203-3.
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spelling pubmed-94685342022-09-13 New-onset systemic lupus erythematosus following BNT162b2 mRNA COVID-19 vaccine: a case series and literature review Sagy, Iftach Zeller, Lior Raviv, Yael Porges, Tzvika Bieber, Amir Abu-Shakra, Mahmoud Rheumatol Int Case Based Review Emerging data evaluated the possible link between the Coronavirus 19 (COVID-19) vaccine and acute flares of rheumatic autoimmune diseases. However, the association between the COVID-19 vaccine and the development of de-novo rheumatic autoimmune diseases remained unclear. We report the first case series of three male patients who developed new-onset systemic lupus erythematosus following receiving Pfizer BNT162b2 mRNA vaccination. The clinical characteristics share some similarities with drug-induced lupus. More patients with SLE following COVID-19 may be diagnosed in the future. Additional studies will provide more significant insights into the possible immunogenic influence of the COVID-19 vaccine. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00296-022-05203-3. Springer Berlin Heidelberg 2022-09-13 2022 /pmc/articles/PMC9468534/ /pubmed/36098769 http://dx.doi.org/10.1007/s00296-022-05203-3 Text en © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022, Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Case Based Review
Sagy, Iftach
Zeller, Lior
Raviv, Yael
Porges, Tzvika
Bieber, Amir
Abu-Shakra, Mahmoud
New-onset systemic lupus erythematosus following BNT162b2 mRNA COVID-19 vaccine: a case series and literature review
title New-onset systemic lupus erythematosus following BNT162b2 mRNA COVID-19 vaccine: a case series and literature review
title_full New-onset systemic lupus erythematosus following BNT162b2 mRNA COVID-19 vaccine: a case series and literature review
title_fullStr New-onset systemic lupus erythematosus following BNT162b2 mRNA COVID-19 vaccine: a case series and literature review
title_full_unstemmed New-onset systemic lupus erythematosus following BNT162b2 mRNA COVID-19 vaccine: a case series and literature review
title_short New-onset systemic lupus erythematosus following BNT162b2 mRNA COVID-19 vaccine: a case series and literature review
title_sort new-onset systemic lupus erythematosus following bnt162b2 mrna covid-19 vaccine: a case series and literature review
topic Case Based Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468534/
https://www.ncbi.nlm.nih.gov/pubmed/36098769
http://dx.doi.org/10.1007/s00296-022-05203-3
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