Investigation of CYP3A induction by PF‐05251749 in early clinical development: comparison of linear slope physiologically based pharmacokinetic prediction and biomarker response

PF‐05251749 is a dual inhibitor of casein kinase 1 δ/ε under clinical development to treat disruption of circadian rhythm in Alzheimer's and Parkinson's diseases. In vitro, PF‐05251749 (0.3–100 μM) induced CYP3A in cryopreserved human hepatocytes, demonstrating non‐saturable, dose–dependen...

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Detalles Bibliográficos
Autores principales: Lin, Jian, Gaudreault, Francois, Johnson, Nathaniel, Lin, Zhiwu, Nouri, Parya, Goosen, Theunis C., Sawant‐Basak, Aarti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468555/
https://www.ncbi.nlm.nih.gov/pubmed/35730131
http://dx.doi.org/10.1111/cts.13352

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