Cargando…

The prognostic value of MicroRNAs associated with fatty acid metabolism in head and neck squamous cell carcinoma

Head and neck squamous cell carcinoma (HNSCC) is the sixth most frequent cancer in humans globally. In addition to smoking and drinking, genetic and epigenetic changes also play a big role in how HNSCC starts and grows. MicroRNAs are short, non-coding RNAs that control cell differentiation and apopt...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Xiaojing, Zhao, Yue, Strohmer, Dorothee Franziska, Yang, Wenjin, Xia, Zhijia, Yu, Cong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468645/
https://www.ncbi.nlm.nih.gov/pubmed/36110217
http://dx.doi.org/10.3389/fgene.2022.983672
_version_ 1784788459315003392
author Wang, Xiaojing
Zhao, Yue
Strohmer, Dorothee Franziska
Yang, Wenjin
Xia, Zhijia
Yu, Cong
author_facet Wang, Xiaojing
Zhao, Yue
Strohmer, Dorothee Franziska
Yang, Wenjin
Xia, Zhijia
Yu, Cong
author_sort Wang, Xiaojing
collection PubMed
description Head and neck squamous cell carcinoma (HNSCC) is the sixth most frequent cancer in humans globally. In addition to smoking and drinking, genetic and epigenetic changes also play a big role in how HNSCC starts and grows. MicroRNAs are short, non-coding RNAs that control cell differentiation and apoptosis by interfering with gene expression. In addition, microRNAs in HNSCC have been shown to affect the clinical behaviors of HNSCC in amazing ways. Moreover, metabolic reprogramming is a key part of cancer and is needed for cancer to turn into a tumor and grow. But it is still not clear what effect microRNAs related to fatty acid metabolism have on the prognosis of HNSCC patients. We downloaded the data of HNSCC patients from the TCGA database and obtained the genes associated with fatty acid metabolism according to the GSEA database. Then, the microRNAs associated with fatty acid metabolism genes were matched. Finally, fatty acid metabolism gene-associated microRNAs for calculating risk scores and then building multifactorial Cox regression models in patients with HNSCC. Heatmap analysis showed that microRNAs involved in fatty acid metabolism were significantly different in HNSCC patients than in healthy controls. A total of 27 microRNAs associated with fatty acid metabolism were screened by univariate Cox analysis (p < 0.05). Using lasso regression, 18 microRNAs substantially linked with the prognosis of HNSCC patients were identified and included in risk scores. The ROC curves demonstrate that risk scores derived from microRNAs involved in fatty acid metabolism can accurately predict the prognosis of HNSCC patients at 1, 3, and 5 years. Moreover, we discovered that 11 microRNAs included in the risk score properly distinguished the prognosis of HNSCC patients. This paper indicated that microRNAs involved with fatty acid metabolism are strongly linked to the prognosis of HNSCC patients. It also indicated that reprogramming of fatty acid metabolism in tumor tissues may play an important role in HNSCC cancer.
format Online
Article
Text
id pubmed-9468645
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-94686452022-09-14 The prognostic value of MicroRNAs associated with fatty acid metabolism in head and neck squamous cell carcinoma Wang, Xiaojing Zhao, Yue Strohmer, Dorothee Franziska Yang, Wenjin Xia, Zhijia Yu, Cong Front Genet Genetics Head and neck squamous cell carcinoma (HNSCC) is the sixth most frequent cancer in humans globally. In addition to smoking and drinking, genetic and epigenetic changes also play a big role in how HNSCC starts and grows. MicroRNAs are short, non-coding RNAs that control cell differentiation and apoptosis by interfering with gene expression. In addition, microRNAs in HNSCC have been shown to affect the clinical behaviors of HNSCC in amazing ways. Moreover, metabolic reprogramming is a key part of cancer and is needed for cancer to turn into a tumor and grow. But it is still not clear what effect microRNAs related to fatty acid metabolism have on the prognosis of HNSCC patients. We downloaded the data of HNSCC patients from the TCGA database and obtained the genes associated with fatty acid metabolism according to the GSEA database. Then, the microRNAs associated with fatty acid metabolism genes were matched. Finally, fatty acid metabolism gene-associated microRNAs for calculating risk scores and then building multifactorial Cox regression models in patients with HNSCC. Heatmap analysis showed that microRNAs involved in fatty acid metabolism were significantly different in HNSCC patients than in healthy controls. A total of 27 microRNAs associated with fatty acid metabolism were screened by univariate Cox analysis (p < 0.05). Using lasso regression, 18 microRNAs substantially linked with the prognosis of HNSCC patients were identified and included in risk scores. The ROC curves demonstrate that risk scores derived from microRNAs involved in fatty acid metabolism can accurately predict the prognosis of HNSCC patients at 1, 3, and 5 years. Moreover, we discovered that 11 microRNAs included in the risk score properly distinguished the prognosis of HNSCC patients. This paper indicated that microRNAs involved with fatty acid metabolism are strongly linked to the prognosis of HNSCC patients. It also indicated that reprogramming of fatty acid metabolism in tumor tissues may play an important role in HNSCC cancer. Frontiers Media S.A. 2022-08-30 /pmc/articles/PMC9468645/ /pubmed/36110217 http://dx.doi.org/10.3389/fgene.2022.983672 Text en Copyright © 2022 Wang, Zhao, Strohmer, Yang, Xia and Yu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Wang, Xiaojing
Zhao, Yue
Strohmer, Dorothee Franziska
Yang, Wenjin
Xia, Zhijia
Yu, Cong
The prognostic value of MicroRNAs associated with fatty acid metabolism in head and neck squamous cell carcinoma
title The prognostic value of MicroRNAs associated with fatty acid metabolism in head and neck squamous cell carcinoma
title_full The prognostic value of MicroRNAs associated with fatty acid metabolism in head and neck squamous cell carcinoma
title_fullStr The prognostic value of MicroRNAs associated with fatty acid metabolism in head and neck squamous cell carcinoma
title_full_unstemmed The prognostic value of MicroRNAs associated with fatty acid metabolism in head and neck squamous cell carcinoma
title_short The prognostic value of MicroRNAs associated with fatty acid metabolism in head and neck squamous cell carcinoma
title_sort prognostic value of micrornas associated with fatty acid metabolism in head and neck squamous cell carcinoma
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468645/
https://www.ncbi.nlm.nih.gov/pubmed/36110217
http://dx.doi.org/10.3389/fgene.2022.983672
work_keys_str_mv AT wangxiaojing theprognosticvalueofmicrornasassociatedwithfattyacidmetabolisminheadandnecksquamouscellcarcinoma
AT zhaoyue theprognosticvalueofmicrornasassociatedwithfattyacidmetabolisminheadandnecksquamouscellcarcinoma
AT strohmerdorotheefranziska theprognosticvalueofmicrornasassociatedwithfattyacidmetabolisminheadandnecksquamouscellcarcinoma
AT yangwenjin theprognosticvalueofmicrornasassociatedwithfattyacidmetabolisminheadandnecksquamouscellcarcinoma
AT xiazhijia theprognosticvalueofmicrornasassociatedwithfattyacidmetabolisminheadandnecksquamouscellcarcinoma
AT yucong theprognosticvalueofmicrornasassociatedwithfattyacidmetabolisminheadandnecksquamouscellcarcinoma
AT wangxiaojing prognosticvalueofmicrornasassociatedwithfattyacidmetabolisminheadandnecksquamouscellcarcinoma
AT zhaoyue prognosticvalueofmicrornasassociatedwithfattyacidmetabolisminheadandnecksquamouscellcarcinoma
AT strohmerdorotheefranziska prognosticvalueofmicrornasassociatedwithfattyacidmetabolisminheadandnecksquamouscellcarcinoma
AT yangwenjin prognosticvalueofmicrornasassociatedwithfattyacidmetabolisminheadandnecksquamouscellcarcinoma
AT xiazhijia prognosticvalueofmicrornasassociatedwithfattyacidmetabolisminheadandnecksquamouscellcarcinoma
AT yucong prognosticvalueofmicrornasassociatedwithfattyacidmetabolisminheadandnecksquamouscellcarcinoma