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Endocytosis of the thrombopoietin receptor Mpl regulates megakaryocyte and erythroid maturation in mice

Dnm2(fl/fl) Pf4-Cre (Dnm2(Plt–/–) ) mice lacking the endocytic GTPase dynamin 2 (DNM2) in platelets and megakaryocytes (MKs) develop hallmarks of myelofibrosis. At the cellular level, the tyrosine kinase JAK2 is constitutively active but decreased in expression in Dnm2(Plt–/–) platelets. Additionall...

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Detalles Bibliográficos
Autores principales:	Eaton, Nathan, Boyd, Emily K., Biswas, Ratnashree, Lee-Sundlov, Melissa M., Dlugi, Theresa A., Ramsey, Haley E., Zheng, Shikan, Burns, Robert T., Sola-Visner, Martha C., Hoffmeister, Karin M., Falet, Hervé
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468709/ https://www.ncbi.nlm.nih.gov/pubmed/36110936 http://dx.doi.org/10.3389/fonc.2022.959806

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