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Strategies for Mammalian Mesenchymal Stem Cells Differentiation into Primordial Germ Cell-Like Cells: A Review
Primordial germ cells develop into oocytes and sperm cells. These cells are useful resources in reproductive biology and regenerative medicine. The mesenchymal stem cells (MSCs) have been examined for in vitro production of primordial germ cell-like cells (PGLCs). This study aimed to summarize the e...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Royan Institute
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468722/ https://www.ncbi.nlm.nih.gov/pubmed/36093802 http://dx.doi.org/10.22074/cellj.2022.8087 |
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author | Fayezi, Shabnam Fayyazpour, Parisa Norouzi, Zahra Mehdizadeh, Amir |
author_facet | Fayezi, Shabnam Fayyazpour, Parisa Norouzi, Zahra Mehdizadeh, Amir |
author_sort | Fayezi, Shabnam |
collection | PubMed |
description | Primordial germ cells develop into oocytes and sperm cells. These cells are useful resources in reproductive biology and regenerative medicine. The mesenchymal stem cells (MSCs) have been examined for in vitro production of primordial germ cell-like cells (PGLCs). This study aimed to summarize the existing protocols for MSCs differentiation into PGLCs. In limited identified studies, various models of MSCs, including those derived from adipose tissue, bone marrow, and Wharton's jelly, have been successfully differentiated in to PGLCs. Although the protocols of specification induction are basically very similar, they have been adjusted to the mesenchymal cell type and the species of origin. The availability of MSCs has made it possible to customize conditions for their differentiation into PGLCs in several models, including humans. Refining germ cell-related signaling pathways during induced differentiation of MSCs will help to define extension to the protocols for PGLCs production. |
format | Online Article Text |
id | pubmed-9468722 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Royan Institute |
record_format | MEDLINE/PubMed |
spelling | pubmed-94687222022-09-24 Strategies for Mammalian Mesenchymal Stem Cells Differentiation into Primordial Germ Cell-Like Cells: A Review Fayezi, Shabnam Fayyazpour, Parisa Norouzi, Zahra Mehdizadeh, Amir Cell J Review Article Primordial germ cells develop into oocytes and sperm cells. These cells are useful resources in reproductive biology and regenerative medicine. The mesenchymal stem cells (MSCs) have been examined for in vitro production of primordial germ cell-like cells (PGLCs). This study aimed to summarize the existing protocols for MSCs differentiation into PGLCs. In limited identified studies, various models of MSCs, including those derived from adipose tissue, bone marrow, and Wharton's jelly, have been successfully differentiated in to PGLCs. Although the protocols of specification induction are basically very similar, they have been adjusted to the mesenchymal cell type and the species of origin. The availability of MSCs has made it possible to customize conditions for their differentiation into PGLCs in several models, including humans. Refining germ cell-related signaling pathways during induced differentiation of MSCs will help to define extension to the protocols for PGLCs production. Royan Institute 2022-08 2022-08-28 /pmc/articles/PMC9468722/ /pubmed/36093802 http://dx.doi.org/10.22074/cellj.2022.8087 Text en Any use, distribution, reproduction or abstract of this publication in any medium, with the exception of commercial purposes, is permitted provided the original work is properly cited. https://creativecommons.org/licenses/by-nc/3.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial 3.0 (CC BY-NC 3.0) License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Fayezi, Shabnam Fayyazpour, Parisa Norouzi, Zahra Mehdizadeh, Amir Strategies for Mammalian Mesenchymal Stem Cells Differentiation into Primordial Germ Cell-Like Cells: A Review |
title | Strategies for Mammalian Mesenchymal Stem Cells Differentiation
into Primordial Germ Cell-Like Cells: A Review |
title_full | Strategies for Mammalian Mesenchymal Stem Cells Differentiation
into Primordial Germ Cell-Like Cells: A Review |
title_fullStr | Strategies for Mammalian Mesenchymal Stem Cells Differentiation
into Primordial Germ Cell-Like Cells: A Review |
title_full_unstemmed | Strategies for Mammalian Mesenchymal Stem Cells Differentiation
into Primordial Germ Cell-Like Cells: A Review |
title_short | Strategies for Mammalian Mesenchymal Stem Cells Differentiation
into Primordial Germ Cell-Like Cells: A Review |
title_sort | strategies for mammalian mesenchymal stem cells differentiation
into primordial germ cell-like cells: a review |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468722/ https://www.ncbi.nlm.nih.gov/pubmed/36093802 http://dx.doi.org/10.22074/cellj.2022.8087 |
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